| Mineralocorticoid hypertension. | |
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MedLine Citation:
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PMID: 10218547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension with hypokalaemia and suppression of plasma renin activity is known as mineralocorticoid hypertension. Although mineralocorticoid hypertension accounts for a small number of patients labelled as having "essential" hypertension, it is a potentially reversible cause of high blood pressure. The most common cause of mineralocorticoid hypertension is probably primary aldosteronism; controlled posture studies to measure plasma renin activity and aldosterone concentrations, followed by adrenal imaging, will ensure the differential diagnosis between an aldosterone-producing adenoma and idiopathic adrenal hyperplasia in most cases. Three monogenic forms of mineralocorticoid hypertension have been described: glucocorticoid-suppressible hyperaldosteronism, Liddle's syndrome, and apparent mineralocorticoid excess, which have provided new insights into mineralocorticoid hormone action. Many patients with mineralocorticoid-based hypertension are now known to have normal serum potassium concentrations. Until the true prevalence of primary aldosteronism and monogenic forms of mineralocorticoid hypertension are defined, a high index of suspicion is needed in every hypertensive patient. Hypertensive patients with hypokalaemia, together with those with severe hypertension or a family history of hypertension or stroke, should be screened for mineralocorticoid excess. |
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Authors:
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P M Stewart |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Lancet Volume: 353 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1341-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK. p.m.stewart@bham.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Humans Hyperaldosteronism / epidemiology, genetics* Hypertension / epidemiology, etiology*, genetics Hypokalemia / genetics Mineralocorticoids* / secretion Prevalence |
| Chemical | |
Reg. No./Substance:
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0/Mineralocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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