| Mineralocorticoid hypertension and hypokalemia. | |
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MedLine Citation:
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PMID: 17275580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mineralocorticoid hypertension is hypertension associated with the presence of hypokalemia, metabolic alkalosis, and suppression of plasma renin. Mineralocorticoid hypertension represents only 10% of patients with essential hypertension. However, its recognition is important because it is a potentially reversible cause of hypertension. Primary hyperaldosteronism is the most common form of mineralocorticoid hypertension. It is current clinical practice to use the plasma aldosterone-renin ratio and the absolute plasma aldosterone level as screening tests. Confirmatory suppression tests and adrenal imaging are performed in appropriate patients. Three monogenic forms of mineralocorticoid hypertension have been identified including Liddle's syndrome, glucocorticoid-remediable hypertension, and apparent mineralocorticoid excess. In a number of patients with mineralocorticoid hypertension, hypokalemia can be a variable finding. This review highlights mineralocorticoid biology and important features of primary hyperaldosteronism and monogenic hypertension. |
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Authors:
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Neenoo Khosla; Donn Hogan |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in nephrology Volume: 26 ISSN: 0270-9295 ISO Abbreviation: Semin. Nephrol. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2007-02-05 Completed Date: 2007-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 434-40 Citation Subset: IM |
Affiliation:
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Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. nkhosla@nmff.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkalosis
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blood,
complications,
diagnosis Blood Pressure / physiology Diagnosis, Differential Humans Hypertension / blood, complications*, diagnosis Hypokalemia / blood, complications*, diagnosis Mineralocorticoids / blood* Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Mineralocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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