| Mineral volume and morphology in carotid plaque specimens using high-resolution MRI and CT. | |
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MedLine Citation:
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PMID: 15947239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: High-resolution MRI methods have been used to evaluate carotid artery atherosclerotic plaque content. The purpose of this study was to assess the performance of high-resolution MRI in evaluation of the quantity and pattern of mineral deposition in carotid endarterectomy (CEA) specimens, with quantitative micro-CT as the gold standard. METHODS AND RESULTS: High-resolution MRI and CT were compared in 20 CEA specimens. Linear regression comparing mineral volumes generated from CT (VCT) and MRI (VMRI) data demonstrated good correlation using simple thresholding (VMRI=-0.01+0.98VCT; R2=0.90; threshold=4xnoise) and k-means clustering methods (VMRI=-0.005+1.38VCT; R2=0.93). Bone mineral density (BMD) and bone mineral content (BMC [mineral mass]) were calculated for CT data and BMC verified with ash weight. Patterns of mineralization like particles, granules, and sheets were more clearly depicted on CT. CONCLUSIONS: Mineral volumes generated from MRI or CT data were highly correlated. CT provided a more detailed depiction of mineralization patterns and provided BMD and BMC in addition to mineral volume. The extent of mineralization as well as the morphology may ultimately be useful in assessing plaque stability. |
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Authors:
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Ronald L Wolf; Suzanne L Wehrli; Andra M Popescu; John H Woo; Hee Kwon Song; Alexander C Wright; Emile R Mohler; John D Harding; Eric L Zager; Ronald M Fairman; Michael A Golden; Omaida C Velazquez; Jeffrey P Carpenter; Felix W Wehrli |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2005-06-09 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 25 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-01 Completed Date: 2005-12-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1729-35 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, Philadelphia, PA 19104, USA. Ronald.Wolf@uphs.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carotid Artery Diseases / metabolism, pathology*, radiography* Evaluation Studies as Topic Female Humans Magnetic Resonance Imaging / methods*, standards Male Middle Aged Minerals / metabolism* Reproducibility of Results Tomography, X-Ray Computed / methods*, standards |
| Grant Support | |
ID/Acronym/Agency:
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K23 NS043381-04/NS/NINDS NIH HHS; K23 NS43381/NS/NINDS NIH HHS; K25 EB001427/EB/NIBIB NIH HHS; KO8 HL03974/HL/NHLBI NIH HHS; R01 HL68908/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Minerals |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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