Document Detail

Mineral-bone metabolism markers in young hemodialysis patients.
MedLine Citation:
PMID:  21933667     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To study the most frequent markers of mineral-bone metabolism in young hemodialysis (HD) patients in order to detect any metabolism changes that could lead to the atherosclerosis and extravascular calcification frequently observed in chronic kidney disease (CKD) patients and estimate their potential prognostic significance. DESIGN AND METHODS: We measured serum levels of intact-PTH (iPTH), Osteoprotegerin (OPG), total soluble receptor activator of nuclear factor-κB ligand (sRANKL), tartrate-resistant acid phosphatase (TRAP-5b), osteocalcin (Oc), bone-specific alkaline phosphatase (BAP), calcium, phosphorus, 25(OH)D(3) and 1,25 (0H)(2)D(3) in young HD patients and controls RESULTS: In comparison to controls, serum OPG, iPTH, BAP, phosphorus, and osteocalcin levels were higher whereas 25(OH)D(3) and 1,25(OH)(2)D(3) were lower in HD patients. CONCLUSION: In conclusion, our results indicate that bone formation and resorption parameters are already altered in young HD subjects. These changes may lead to vascular calcifications and cardiovascular complications, given that elevated OPG levels predict cardiovascular events in HD patients. Furthermore, low levels of vitamin D metabolites have been associated with the presence of vascular calcification.
Alvaro Osorio; Esperanza Ortega; Jesús M Torres; Pilar Sanchez; Estrella Ruiz-Requena
Related Documents :
22841657 - Net-like pattern of calcification on plain soft-tissue radiographs in patients with cal...
21737807 - Intravenous thrombolysis of basilar artery occlusion: predictors of recanalization and ...
21920867 - Changes in integrity of normal-appearing white matter in patients with moyamoya disease...
22193377 - Cytokine profile, foxp3 and nuclear factor-kb ligand levels in multiple sclerosis subty...
12771267 - Immediate reocclusion following a successful thrombolysis in acute stroke: a pilot study.
2254677 - Lack of glutathione transferase activity in intermittent claudication.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-12
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Unit of Vascular Surgery, Virgen de la Luz Hospital, Cuenca, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical significance of conventional serum autoantibodies for various liver diseases in a Chinese p...
Next Document:  Is HbA(1c) a good screening test for diabetes mellitus?