| Mind your salts: when the inactive constituent isn't. | |
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MedLine Citation:
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PMID: 20651116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many pharmacological agents include "inactive" constituents that are used to alter the solubility, stability, or pharmaceutical properties of a drug. These "salts" are often ignored, and the "active ingredient" gets all of the attention. Pamoic acid (4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid) has been used in formulations of several drugs as pamoate salts. This Perspective highlights an Accelerated Communication in this issue (p. 560) that identifies pamoic acid as a potent activator of the orphan G protein-coupled receptor GPR35. This effect may contribute to the pharmacological actions of some agents that are prepared as pamoate salts. Thus, pharmacologists, regulators, and clinicians should "mind their salts" in considering differences among supposedly equivalent agents. |
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Authors:
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Richard R Neubig |
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Publication Detail:
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Type: Comment; Journal Article; Review Date: 2010-07-22 |
Journal Detail:
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Title: Molecular pharmacology Volume: 78 ISSN: 1521-0111 ISO Abbreviation: Mol. Pharmacol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-10-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0035623 Medline TA: Mol Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 558-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-0632, USA. rneubig@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemistry, Pharmaceutical / methods* Humans Naphthols / pharmacology Pharmaceutical Preparations / chemistry* Receptors, G-Protein-Coupled / metabolism Salts / chemistry* Solubility |
| Chemical | |
Reg. No./Substance:
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0/GPR35 protein, human; 0/Naphthols; 0/Pharmaceutical Preparations; 0/Receptors, G-Protein-Coupled; 0/Salts; 130-85-8/pamoic acid |
| Comments/Corrections | |
Comment On:
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Mol Pharmacol. 2010 Oct;78(4):560-8
[PMID:
20826425
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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