Document Detail


Mimicking Native Extracellular Matrix with Phytic Acid-Crosslinked Protein Nanofibers for Cardiac Tissue Engineering.
MedLine Citation:
PMID:  23335565     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A functional scaffold fabricated is developed from natural polymers, favoring regeneration of the ischemic myocardium. Hemoglobin/gelatin/fibrinogen (Hb/gel/fib) nanofibers are fabricated by electrospinning and are characterized for morphology, scaffold composition, functional groups and hydrophilicity. It is hypothesized that ex vivo pretreatment of mesenchymal stem cells (MSCs) using 5-azacytidine and such a functional nanofibrous construct having a high oxygen-carrying potential could lead to enhanced cardiomyogenic differentiation of MSCs and result in superior biological and functional effects. The combination of a functional nanofibrous scaffold composed of natural polymers and crosslinked with a natural crosslinking agent, phytic acid, and stem cell biology may prove to be a novel therapeutic device for treatment of myocardial infarction.
Authors:
Rajeswari Ravichandran; Vera Seitz; Jayarama Reddy Venugopal; Radhakrishnan Sridhar; Subramanian Sundarrajan; Shayanti Mukherjee; Erich Wintermantel; Seeram Ramakrishna
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  Macromolecular bioscience     Volume:  -     ISSN:  1616-5195     ISO Abbreviation:  Macromol Biosci     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Health care and Energy Materials Laboratory, Nanoscience and Nanotechnology Initiative, National University of Singapore, Faculty of Engineering, 2 Engineering Drive 3, Singapore 117576; Department of Mechanical Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576.
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