| Mimicking Native Extracellular Matrix with Phytic Acid-Crosslinked Protein Nanofibers for Cardiac Tissue Engineering. | |
| | |
MedLine Citation:
|
PMID: 23335565 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
A functional scaffold fabricated is developed from natural polymers, favoring regeneration of the ischemic myocardium. Hemoglobin/gelatin/fibrinogen (Hb/gel/fib) nanofibers are fabricated by electrospinning and are characterized for morphology, scaffold composition, functional groups and hydrophilicity. It is hypothesized that ex vivo pretreatment of mesenchymal stem cells (MSCs) using 5-azacytidine and such a functional nanofibrous construct having a high oxygen-carrying potential could lead to enhanced cardiomyogenic differentiation of MSCs and result in superior biological and functional effects. The combination of a functional nanofibrous scaffold composed of natural polymers and crosslinked with a natural crosslinking agent, phytic acid, and stem cell biology may prove to be a novel therapeutic device for treatment of myocardial infarction. |
| | |
Authors:
|
Rajeswari Ravichandran; Vera Seitz; Jayarama Reddy Venugopal; Radhakrishnan Sridhar; Subramanian Sundarrajan; Shayanti Mukherjee; Erich Wintermantel; Seeram Ramakrishna |
Related Documents
:
|
7712835 - Increased vulnerability of hypertrophied myocardium to ischemia and reperfusion injury.... 7015815 - The "border zone" in evolving myocardial infarction: controversy or confusion? 23071585 - The association of growth differentiation factor-15 with left ventricular hypertrophy i... 10564165 - Chronic dipyridamole therapy produces sustained protection against cardiac ischemia-rep... 3581835 - Bedside intracoronary thrombolysis in the coronary care unit. 12932595 - Synergistic treatment of st-segment elevation myocardial infarction with pharmacoinvasi... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-18 |
Journal Detail:
|
Title: Macromolecular bioscience Volume: - ISSN: 1616-5195 ISO Abbreviation: Macromol Biosci Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Health care and Energy Materials Laboratory, Nanoscience and Nanotechnology Initiative, National University of Singapore, Faculty of Engineering, 2 Engineering Drive 3, Singapore 117576; Department of Mechanical Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization of the Yeast Actin Patch Protein App1p Phosphatidate Phosphatase.
Next Document: Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camp...