Document Detail

Mimetics of L-histidinol which selectively modulate daunomycin toxicity in normal and tumorigenic epithelial cells.
MedLine Citation:
PMID:  9042234     Owner:  NLM     Status:  MEDLINE    
In the accompanying publication, it was shown that L-histidinol protected the normal Madin-Darby canine kidney (MDCK) epithelial cell line from daunomycin (DAU) toxicity, but enhanced DAU toxicity in MDCK-T1, a tumorigenic derivative of MDCK. The protection of MDCK cells from DAU by L-histidinol was also shown to be independent of its ability to inhibit protein synthesis. Here, clonogenic cell survival assays show that imidazole was as effective as L-histidinol in protecting MDCK cells from DAU, but had less impact on MDCK-T1 line. Certain antieicosanoids and antihistamines mimicked, to varying extents, the DAU-modulating action of L-histidinol. These data suggest that the selective modulation of DAU toxicity by L-histidinol involves both inhibition of protein synthesis and unknown action(s) attributable to its imidazole moiety and that other pharmacological agents are modulators of anticancer drug toxicity.
R C Warrington; W D Fang; L Zhang; M Shieh; M H Saier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  16     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-03-27     Completed Date:  1997-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  3635-9     Citation Subset:  IM    
Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Antibiotics, Antineoplastic / pharmacology*
Cell Line / drug effects
Daunorubicin / pharmacology*
Drug Interactions
Eicosanoids / antagonists & inhibitors*
Histamine H1 Antagonists / pharmacology*
Histidinol / pharmacology*
Imidazoles / pharmacology*
Protein Synthesis Inhibitors / pharmacology
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Eicosanoids; 0/Histamine H1 Antagonists; 0/Imidazoles; 0/Protein Synthesis Inhibitors; 20830-81-3/Daunorubicin; 501-28-0/Histidinol

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