| Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine. | |
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MedLine Citation:
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PMID: 17119877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We assessed the dose or timing effect of milrinone administered against myocardial stunning in 37 anesthetized open-chest swine. METHODS: All swine were subjected to 12-min ischemia followed by reperfusion to produce myocardial stunning. Group A (n = 12) received saline in place of milrinone both before and after ischemia. Group B (n = 9) and C (n = 9) received intravenous milrinone at a rate of 5 microg/kg/min for 10 min followed by 0.5 microg/kg/min for 10 min and 10 microg/kg/min for 10 min followed by 1 microg/kg/min for 10 min, respectively, until 30 min before coronary occlusion. Group D (n = 7) received the same dose of milrinone as group B starting 1 min after reperfusion. Myocardial contractility was assessed by percentage segment shortening (%SS). RESULTS: Five swine in group A and two swine in groups B and C each had ventricular fibrillation or tachycardia after reperfusion, and were thus excluded from further analysis. The percentage changes of %SS from the baseline 90 min after reperfusion in groups B, C, and D were 78 +/- 9%, 82 +/- 13%, and 79 +/- 7%, respectively, which were significantly higher than those in group A (43 +/- 13%). CONCLUSION: We conclude that milrinone administered before ischemia or just after reperfusion attenuates myocardial stunning. |
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Authors:
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Tadasuke Use; Tetsuji Makita; Hiroyuki Ureshino; Sungsam Cho; Osamu Yoshitomi; Daiji Akiyama; Motoko Oshibuchi; Tetsuya Hara; Koji Sumikawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 20 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2007-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: United States |
Other Details:
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Languages: eng Pagination: 327-34 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Japan. makita@net.nagasaki-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Cardiotonic Agents / administration & dosage*, blood, pharmacokinetics Female Male Milrinone / administration & dosage*, blood, pharmacokinetics Myocardial Contraction Myocardial Ischemia Myocardial Reperfusion Myocardial Stunning / prevention & control* Phosphodiesterase Inhibitors / administration & dosage*, blood, pharmacokinetics Swine |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Phosphodiesterase Inhibitors; 78415-72-2/Milrinone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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