Document Detail

Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine.
MedLine Citation:
PMID:  17119877     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We assessed the dose or timing effect of milrinone administered against myocardial stunning in 37 anesthetized open-chest swine. METHODS: All swine were subjected to 12-min ischemia followed by reperfusion to produce myocardial stunning. Group A (n = 12) received saline in place of milrinone both before and after ischemia. Group B (n = 9) and C (n = 9) received intravenous milrinone at a rate of 5 microg/kg/min for 10 min followed by 0.5 microg/kg/min for 10 min and 10 microg/kg/min for 10 min followed by 1 microg/kg/min for 10 min, respectively, until 30 min before coronary occlusion. Group D (n = 7) received the same dose of milrinone as group B starting 1 min after reperfusion. Myocardial contractility was assessed by percentage segment shortening (%SS). RESULTS: Five swine in group A and two swine in groups B and C each had ventricular fibrillation or tachycardia after reperfusion, and were thus excluded from further analysis. The percentage changes of %SS from the baseline 90 min after reperfusion in groups B, C, and D were 78 +/- 9%, 82 +/- 13%, and 79 +/- 7%, respectively, which were significantly higher than those in group A (43 +/- 13%). CONCLUSION: We conclude that milrinone administered before ischemia or just after reperfusion attenuates myocardial stunning.
Tadasuke Use; Tetsuji Makita; Hiroyuki Ureshino; Sungsam Cho; Osamu Yoshitomi; Daiji Akiyama; Motoko Oshibuchi; Tetsuya Hara; Koji Sumikawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  20     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  IM    
Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Japan.
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MeSH Terms
Cardiotonic Agents / administration & dosage*,  blood,  pharmacokinetics
Milrinone / administration & dosage*,  blood,  pharmacokinetics
Myocardial Contraction
Myocardial Ischemia
Myocardial Reperfusion
Myocardial Stunning / prevention & control*
Phosphodiesterase Inhibitors / administration & dosage*,  blood,  pharmacokinetics
Reg. No./Substance:
0/Cardiotonic Agents; 0/Phosphodiesterase Inhibitors; 78415-72-2/Milrinone

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