| Millisecond light pulses make mice stop running, then display prolonged sleep-like behavior in the absence of light. | |
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MedLine Citation:
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PMID: 19926809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Masking, measured as a decrease in nocturnal rodent wheel running, is a visual system response to rod/cone and retinal ganglion cell photoreception. Here, the authors show that a few milliseconds of light are sufficient to initiate masking, which continues for many minutes without additional photic stimulation. C57J/B6 mice were tested using flash stimuli previously shown to elicit large circadian rhythm phase shifts. Ten flashes, 2 msec each and equally distributed over 5 min, activate locomotor suppression that endures for an additional 25 to 35 min in the dark and does not differ in magnitude or duration from that elicited by 5-min saturating light pulse. Locomotor activity by mice without access to running wheels is also suppressed by light flashes. The effects of various light flash patterns on mouse locomotor suppression are similar to those previously described for hamster phase shifts. Video analysis of active mice indicates that light flashes initiated at ZT13 rapidly induce an interval of behavioral quiescence that lasts about 10 min at which time the animals assume a typical sleep posture that is maintained for an additional 25 min. Thus, the period coincident with light-induced wheel running suppression appears to consist of two distinct behavioral states, one interval during which locomotor quiescence is initiated and maintained, followed by a second interval characterized by behavioral sleep. Given this sequence effected by light stimulation, we suggest that it be referred to as "photosomnolence," the term reflecting upon both the nature of the stimulus and the associated behavioral change. |
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Authors:
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L P Morin; K M Studholme |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of biological rhythms Volume: 24 ISSN: 1552-4531 ISO Abbreviation: J. Biol. Rhythms Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-01-20 Revised Date: 2011-03-08 |
Medline Journal Info:
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Nlm Unique ID: 8700115 Medline TA: J Biol Rhythms Country: United States |
Other Details:
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Languages: eng Pagination: 497-508 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Stony Brook Medical Center, Stony Brook University, New York, USA. lawrence.morin@stonybrook.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / physiology, radiation effects* Circadian Rhythm / physiology, radiation effects* Light Male Mice Mice, Inbred C57BL Motor Activity / physiology, radiation effects* Photic Stimulation* Running Sleep |
| Grant Support | |
ID/Acronym/Agency:
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NS061804/NS/NINDS NIH HHS; R01 NS022168-21/NS/NINDS NIH HHS; R01 NS061804-01A2/NS/NINDS NIH HHS; R01 NS22168/NS/NINDS NIH HHS |
| Comments/Corrections | |
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