| Millet consumption decreased serum concentration of triglyceride and C-reactive protein but not oxidative status in hyperlipidemic rats. | |
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MedLine Citation:
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PMID: 20534332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to investigate the hypothesis that whole grain consumption would have beneficial effects on lipid profiles, antioxidant status, and the inflammation state of hyperlipidemic rats compared to those resulting from a white rice (WR) diet. Forty-week-old male Sprague-Dawley rats (n = 24) were fed a high-fat diet (188.3 kJ% energy as fat) for 8 weeks to induce hyperlipidemia and were then randomly divided into 4 groups (n = 6 each) that were fed diets containing WR (control), sorghum, foxtail millet (FM), or proso millet for the next 5 weeks. Blood lipid profiles, hepatic antioxidant parameters, and inflammation-related measurements were determined in all of the groups. The concentrations of serum triglycerides were significantly lower in the FM and proso millet groups compared to those of the WR and sorghum groups. The concentrations of serum total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL)-cholesterol were significantly higher in the sorghum group than in the WR, FM, and proso millet groups. Hepatic catalase, superoxide dismutase, and glutathione activities, as well as thiobarbituric acid reactive substance levels were not significantly different between the groups. Levels of C-reactive protein were significantly lower in the FM group than in the WR, sorghum, and proso millet groups. Inhibitor kappaB-alpha was expressed in the liver cytosolic fraction, and nuclear translocation of nuclear factor-kappaB (p65) into the liver nucleus was blocked in all groups. In conclusion, FM and proso millet may prevent cardiovascular disease by reducing plasma triglycerides in hyperlipidemic rats; in contrast, sorghum increases total cholesterol, HDL-cholesterol, and LDL-cholesterol concentrations. |
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Authors:
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Sun Hee Lee; Ill-Min Chung; Youn-Soo Cha; Yongsoon Park |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition research (New York, N.Y.) Volume: 30 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
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Languages: eng Pagination: 290-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Food and Nutrition, Hanyang University, Seoul, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology, therapeutic use* Antioxidants / metabolism C-Reactive Protein / metabolism* Cereals Diet Hyperlipidemias / drug therapy*, metabolism Lipids / blood Liver / enzymology Male NF-kappa B / metabolism Oxidative Stress / drug effects* Panicum* Plant Preparations / pharmacology, therapeutic use* Random Allocation Rats Rats, Sprague-Dawley Sorghum Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Antioxidants; 0/Lipids; 0/NF-kappa B; 0/Plant Preparations; 0/Triglycerides; 9007-41-4/C-Reactive Protein |
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