Document Detail

Milk- and soy-protein ingestion: acute effect on serum uric acid concentration.
MedLine Citation:
PMID:  2000819     Owner:  NLM     Status:  MEDLINE    
Acute effect of the ingestion of 80 g each of casein, lactalbumin, and soybean isolate on serum and urinary uric acid concentrations was investigated in 10 healthy subjects. Serum and urinary uric acid concentrations were measured before and after the ingestion of proteins. Serum uric acid decreased significantly 3 h after ingestion of lactalbumin and casein but increased after soybean consumption. Urate clearance was significantly increased after ingestion of each of the three proteins. Multivariate analysis of urate clearance during lactalbumin and casein loads showed that independent correlation was obtained for serum alanine and urea concentration. These results demonstrate that, in addition to their known uricosuric effect, milk proteins acutely decrease serum uric acid concentration. Analysis of the effects of lactalbumin and casein on urinary uric acid elimination suggests that the uricosuric effect of proteins is a multifactorial phenomenon.
D R Garrel; M Verdy; C PetitClerc; C Martin; D Brulé; P Hamet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  53     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-10     Completed Date:  1991-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  665-9     Citation Subset:  AIM; IM    
Hotel-Dieu de Montreal, Quebec, Canada.
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MeSH Terms
Amino Acids / blood
Analysis of Variance
Caseins / pharmacology*
Creatinine / urine
Dietary Proteins / pharmacology*
Lactalbumin / pharmacology*
Soybean Proteins
Uric Acid / blood*,  urine
Vegetable Proteins / pharmacology*
Reg. No./Substance:
0/Amino Acids; 0/Caseins; 0/Dietary Proteins; 0/Soybean Proteins; 0/Vegetable Proteins; 60-27-5/Creatinine; 69-93-2/Uric Acid; 9013-90-5/Lactalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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