| Milk and linear growth: programming of the igf-I axis and implication for health in adulthood. | |
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MedLine Citation:
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PMID: 21335992 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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There is increasing awareness that childhood circumstances influence disease risk in adulthood. As well as being strongly influenced by genes/genetic factors, stature acts as a marker for early-life exposures, such as diet, and is associated with risk of several chronic diseases in adulthood. Stature is also a marker for levels of insulin-like growth factor (IGF)-I in childhood. Levels of IGF-I are nutritionally regulated and are therefore modifiable. Milk intake in childhood and in adulthood is positively associated with higher levels of circulating IGF-I and, in children, higher circulating IGF-I promotes linear growth. Studies conducted by our team and others, however, indicate that the effect of milk is complicated because consumption in childhood appears to have long-term, programming effects which are opposite to the immediate effects of consuming milk. Specifically, studies suggest that the long-term effect of higher levels of milk intake in early childhood is opposite to the expected short-term effect, because milk intake in early-life is inversely associated with IGF-I levels throughout adult life. We hypothesize that this long-term programming effect is via a resetting of pituitary control in response to raised levels of IGF-I in childhood. Such a programming effect of milk intake in early life could potentially have implications for cancer and ischemic heart disease risk many years later. |
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Authors:
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Richard M Martin; Jeff M P Holly; David Gunnell |
Publication Detail:
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Type: Journal Article Date: 2011-02-16 |
Journal Detail:
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Title: Nestlé Nutrition workshop series. Paediatric programme Volume: 67 ISSN: 1662-3878 ISO Abbreviation: Nestle Nutr Workshop Ser Pediatr Program Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244056 Medline TA: Nestle Nutr Workshop Ser Pediatr Program Country: Switzerland |
Other Details:
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Languages: eng Pagination: 79-97 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Department of Social Medicine, University of Bristol, Bristol, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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