Document Detail

Milk folate secretion is not impaired during iron deficiency in humans.
MedLine Citation:
PMID:  16988136     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to examine whether maternal iron and/or folate status influences human milk folate secretion and is responsible for growth faltering of Otomi infants in Capulhuac, Mexico. Breast-feeding mothers (n = 71) were randomized at 22 +/- 13 d (baseline) postpartum to receive a daily multivitamin supplement containing folic acid (400 microg) with and without iron (18 mg). Mothers provided blood and milk samples at baseline, and at 82 +/- 15 and 138 +/- 18 d postpartum. Iron supplementation significantly improved hematocrit and transferrin receptor concentrations but had no influence on maternal folate status or milk folate or iron concentrations. Forty-three percent of mothers (29/68) had low blood folate concentrations at baseline, whereas only 6% (4/66) had low blood folate concentrations at approximately 138 d postpartum. Milk folate concentrations did not differ between Fe-deficient and Fe-sufficient women and provided adequate levels of dietary folate by approximately 82 d postpartum. While milk iron concentrations were unrelated to maternal iron status, they decreased during lactation, and, by approximately 138 d, they provided only 55% of the current recommendation. In conclusion, milk folate concentrations appear to be well preserved during maternal iron deficiency; hence, faltering growth among infants in Capulhuac, Mexico is unlikely the result of reduced milk folate concentration secondary to maternal Fe deficiency. However, milk Fe concentrations showed a temporal decline. Whether the disjuncture between recommended and actual Fe intakes among infants born with low Fe reserves and weaned to foods low in bioavailable Fe has functional consequences is worthy of further investigation.
Amina Khambalia; Maria E Latulippe; Cristina Campos; Claide Merlos; Salvador Villalpando; Mary Frances Picciano; Deborah L O'connor
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  136     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-21     Completed Date:  2006-10-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2617-24     Citation Subset:  IM    
Department of Nutritional Sciences, the Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Anemia, Iron-Deficiency / metabolism*
Biological Availability
Breast Feeding
Dietary Supplements
Energy Intake
Folic Acid / administration & dosage,  blood,  secretion*
Iron / analysis
Iron, Dietary / administration & dosage
Maternal Nutritional Physiological Phenomena
Milk, Human / chemistry,  secretion*
Nutritional Status
Postpartum Period
Receptors, Transferrin / blood
Vitamins / administration & dosage
Reg. No./Substance:
0/Iron, Dietary; 0/Receptors, Transferrin; 0/Vitamins; 59-30-3/Folic Acid; 7439-89-6/Iron

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