Document Detail


Milk fat structure of a patient with type 1 hyperlipidemia.
MedLine Citation:
PMID:  6503629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Structural analyses were performed on milk fat samples obtained 3-10 days postpartum from a lactating patient with primary Type 1 hyperlipidemia. The milk triacylglycerols contained 3-7% C10, 14-21% C12, 20-30% C14, 22-26% C16 and 20-30% C18 (largely oleic) acids. Gas liquid chromatographic (GLC) analyses of the X-1,3- and X-1,2-diacylglycerols on polar siloxane columns showed a markedly non-random association of acyl chains. Stereospecific analyses indicated that the short chain length fatty acids were confined essentially to the sn-3-position of the triacylglycerol molecule. Furthermore, these acids were largely absent from the phosphatidylcholines and the endogenous sn-1,2-diacylglycerols of the milk fat. It is concluded that the short chain fatty acids are incorporated into the milk triacylglycerols during the final stage of biosynthesis via the phosphatidic acid pathway, and that the overall fatty acid distribution is consistent with the 1-random 2-random 3-random hypothesis.
Authors:
J J Myher; A Kuksis; G Steiner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  19     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-12-27     Completed Date:  1984-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Gas
Diglycerides / analysis
Fatty Acids / analysis
Female
Horses
Humans
Hyperlipidemias / metabolism*
Lipids / analysis*
Milk / analysis
Milk, Human / analysis*
Pregnancy
Reference Values
Species Specificity
Triglycerides / analysis
Chemical
Reg. No./Substance:
0/Diglycerides; 0/Fatty Acids; 0/Lipids; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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