| Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men. | |
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MedLine Citation:
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PMID: 11471735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Milk contains several components effective for bone health. In the previous in vitro and in vivo studies, we have shown that milk whey protein, especially its basic protein fraction (milk basic protein [MBP]), promoted bone formation and suppressed bone resorption. This present study examines the effect of MBP on the biochemical markers of bone metabolism in healthy adult men. Experimental beverages containing MBP (300 mg of MBP a day) were given to 30 normal healthy adult men for 16 days. The serum osteocalcin concentration had increased significantly after 16 days of ingesting the experimental beverage containing MBP. Urinary cross-linked N-teleopeptides of type-I collagen (NTx) excretion had decreased significantly after 16 days of ingesting MBP. The urinary NTx excretion was related to the serum osteocalcin concentration after 16 days of ingestion. These results suggest that MBP promoted bone formation and suppressed bone resorption, while maintaining the balance of bone remodeling. |
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Authors:
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Y Toba; Y Takada; Y Matsuoka; Y Morita; M Motouri; T Hirai; T Suguri; S Aoe; H Kawakami; M Kumegawa; A Takeuchi; A Itabashi |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 65 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-07-26 Completed Date: 2001-12-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 1353-7 Citation Subset: IM |
Affiliation:
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Technology and Research Institute, Snow Brand Milk Products Co. Ltd., Kawagoe, Saitama, Japan. yasutoba@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers Bone Development / drug effects* Bone Resorption / prevention & control* Calcium / blood, urine Collagen Type I / urine Humans Male Milk Proteins / pharmacology*, therapeutic use* Osteocalcin / blood Peptide Fragments / blood Procollagen / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Collagen Type I; 0/Milk Proteins; 0/Peptide Fragments; 0/Procollagen; 0/procollagen type I carboxy terminal peptide; 104982-03-8/Osteocalcin; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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