| Milk A1 and A2 peptides and diabetes. | |
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MedLine Citation:
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PMID: 21335999 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Food-derived peptides, specifically those derived from milk, may adversely affect health by increasing the risk of insulin-dependent diabetes. This position is based on the relationship of type 1 diabetes (T1D) and the consumption of variants A1 and B β-casein from cow's milk. It appears that β-casomorphin-7 (BCM-7) from β-casein may function as an immunosuppressant and impair tolerance to dietary antigens in the gut immune system, which, in turn, may contribute to the onset of T1D. There are thirteen genetic variants of β-casein in dairy cattle. Among those variants are A1, A2, and B, which are also found in human milk. The amino acid sequences of β-casomorphins among these bovine variants and those found in human milk are similar, often differing only by a single amino acid. In vitro studies indicate BCM-7 can be produced from A1 and B during typical digestive processes; however, BCM-7 is not a product of A2 digestion. Evidence from several epidemiological studies and animal models does not support the association of milk proteins, even proteins in breast milk, and the development of T1D. Ecological data, primarily based on A1/ A2 variations among livestock breeds, do not demonstrate causation, even among countries where there is considerable dairy consumption. |
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Authors:
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Roger A Clemens |
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Publication Detail:
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Type: Journal Article Date: 2011-02-16 |
Journal Detail:
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Title: Nestlé Nutrition workshop series. Paediatric programme Volume: 67 ISSN: 1662-3878 ISO Abbreviation: Nestle Nutr Workshop Ser Pediatr Program Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244056 Medline TA: Nestle Nutr Workshop Ser Pediatr Program Country: Switzerland |
Other Details:
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Languages: eng Pagination: 187-95 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Regulatory Science, School of Pharmacy, University of Southern California, Los Angeles, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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