| Miliary tuberculosis associated with chronic neutrophilic leukemia. | |
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MedLine Citation:
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PMID: 19652431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of miliary tuberculosis associated with chronic neutrophilic leukemia (CNL). A 70-year-old woman was referred to our hospital complaining of a 1-month history of persistent fever and anorexia. Chest and abdominal computed tomography images revealed diffuse small nodular lesions in the bilateral lung fields and extreme splenomegaly. Sputum cultures isolated Mycobacterium tuberculosis. After anti-tuberculous therapy for 1 year, the patient underwent splenectomy for massive splenomegaly and progressive leukocytosis. The presence of the homozygous JAK2 V617F tyrosine kinase mutation was also demonstrated in the peripheral blood. She was finally diagnosed as having miliary tuberculosis associated with CNL based on the histopathological examination of spleen. The patient was treated with a daily dose of 500 mg of hydroxyurea. As a result, 18 months after the splenectomy, her leukocyte count was decreased and her clinical condition was markedly improved; there was no relapse of the CNL. |
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Authors:
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Keishi Sugino; Kyoko Gocho; Hiroki Ota; Minaho Kobayashi; Go Sano; Kazutoshi Isobe; Yujiro Takai; Haruka Izumi; Yasunobu Kuraishi; Kazutoshi Shibuya; Sakae Homma |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-08-03 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 48 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-08-04 Completed Date: 2009-11-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1283-7 Citation Subset: IM |
Affiliation:
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Division of Respiratory Medicine, Toho University Omori Medical Center, Tokyo. keishi_sugino@ybb.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bone Marrow / pathology Female Homozygote Humans Janus Kinase 2 / genetics Leukemia, Neutrophilic, Chronic / complications*, diagnosis*, enzymology, genetics Mutation, Missense Spleen / pathology Tomography, X-Ray Computed Tuberculosis, Miliary / complications*, diagnosis* Tuberculosis, Splenic / complications, diagnosis |
| Chemical | |
Reg. No./Substance:
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EC 2.7.1.112/JAK2 protein, human; EC 2.7.10.1/Janus Kinase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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