Document Detail


Milestones in umbilical cord blood transplantation.
MedLine Citation:
PMID:  21726206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Much has been learned about umbilical cord blood (UCB) since the first human cord blood transplant was performed back in 1988. Cord blood banks have been established worldwide for the collection, cryopreservation and distribution of UCB for allogeneic haematopoietic stem cell transplantation. UCB has now become one of the most commonly used sources of haematopoietic stem cells for allogeneic transplantation. Today, a global network of cord blood banks and transplant centres has been established with a large common inventory, allowing for more than 20000 transplants worldwide in children and adults with severe haematological diseases. Several studies have been published on UCB transplant, assessing risk factors such as cell dose and human leucocyte antigen mismatch. New strategies are ongoing to facilitate engraftment and reduce transplant-related mortality and include the use of reduced-intensity conditioning regimen, intra-bone injection of cord blood cells, double cord blood transplants or ex vivo expansion of cord blood cells. The absence of ethical concern and the unlimited supply of cells explain the increasing interest of using UCB for developing regenerative medicine.
Authors:
Eliane Gluckman; Annalisa Ruggeri; Fernanda Volt; Renato Cunha; Karim Boudjedir; Vanderson Rocha
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-05
Journal Detail:
Title:  British journal of haematology     Volume:  154     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-28     Completed Date:  2011-10-03     Revised Date:  2013-01-04    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-7     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Eurocord, Assistance publique des hôpitaux de Paris (APHP), Institut Universitaire d'Hématologie (IUH) Hôpital Saint Louis, Paris, France. eliane.gluckman@sls.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Blood Banks / history,  organization & administration
Cord Blood Stem Cell Transplantation / history*,  methods,  trends
Donor Selection
Hematologic Diseases / history,  therapy
Histocompatibility
History, 20th Century
History, 21st Century
Humans
Comments/Corrections
Comment In:
Br J Haematol. 2012 Dec;159(5):602-4   [PMID:  23043219 ]

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