| Mild-to-moderate renal impairment is associated with platelet activation: a cross-sectional study. | |
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MedLine Citation:
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PMID: 18826858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The high incidence of cardiovascular disease in patients with moderate renal impairment is not fully explained by traditional atherothrombotic risk factors. Independently from these factors, blood platelet activation may increase the cardiovascular disease risk of patients with mild-to-moderate renal impairment. Blood platelet activation has not been studied in nondiabetic patients with mild-to-moderate renal impairment. Therefore, we measured the extent of platelet activation by means of fluorescence cytometry in 93 nondiabetic patients with MDRD-estimated creatinine clearance ranging from 13 - 63 ml/min/1.73 m2. As platelet activation parameters we used the expression of CD62P (P-selectin), CD 63 (glycoprotein 53), PAC-1 (activated fibrinogen receptor), CD42b (von Willebrand factor receptor) and CD41 (fibrinogen receptor) on the platelet surface membrane. The expression of CD62p, CD63 and PAC-1 was statistically significantly inversely related to the estimated glomerular filtration rate in these patients (standardized b -0.28, -0.32 and -0.39, respectively). We conclude that nondiabetic mild-to-moderate renal impairment is associated with blood platelet activation. Whether this contributes to the increased cardiovascular risk in these patients needs further study. |
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Authors:
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A Thijs; P W B Nanayakkara; P M Ter Wee; P C Huijgens; C van Guldener; C D A Stehouwer |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical nephrology Volume: 70 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-01 Completed Date: 2009-01-27 Revised Date: 2010-10-20 |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 325-31 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands. a.thijs@vumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Antigens, CD / blood Antioxidants / therapeutic use Biological Markers / blood* Creatinine / blood Cross-Sectional Studies Double-Blind Method Female Humans Kidney Failure, Chronic / drug therapy, physiopathology* Male Middle Aged P-Selectin / blood Placebos Platelet Activation / physiology* Platelet Membrane Glycoprotein IIb / blood Platelet Membrane Glycoproteins / metabolism Receptors, Fibrinogen / blood Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antioxidants; 0/Biological Markers; 0/CD63 antigen; 0/P-Selectin; 0/Placebos; 0/Platelet Membrane Glycoprotein IIb; 0/Platelet Membrane Glycoproteins; 0/Receptors, Fibrinogen; 0/von Willebrand factor receptor; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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