| Mild-to-moderate malnutrition and small intestine of young rhesus monkeys. | |
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MedLine Citation:
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PMID: 8541700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of severe malnutrition and protein deficiency on small intestine has been documented, but the literature on the effect of mild-to-moderate protein-energy malnutrition (PEM) on small intestine is scant. Mild-to-moderate PEM is most prevalent in India. Twenty-four young rhesus monkeys weighing 1.5-2.0 kg were divided into two groups, control and experimental. Mild-to-moderate PEM was induced in the experimental group by giving half of the required normal diet providing 2.42 g protein.kg-1.day-1 and 55 kcal.kg-1.day-1. Body weight, serum protein, and D-xylose were measured before starting the experiment, at PEM stage, and after rehabilitation. Experimental monkeys representing group I were killed after a 25-30% reduction in body weight along with control group 1 animals at 12 wk. The rest of the experimental animals were rehabilitated for another 10-12 wk and killed along with their respective controls (control group 2). Brush-border membrane vesicles were prepared from three parts of the small intestine. Viable vesicles were used for the uptake of [U-14C]L-proline. Alkaline phosphatase and enterokinase were also measured. Uptake of L-proline amino acid and the activity of both enzymes were found to be decreased significantly in the PEM group; a D-xylose test was abnormal. All animals recovered after rehabilitation. These results indicate that even mild-to-moderate malnutrition affects the absorptive and digestive capacity of the brush border of the small intestine, which reversed back on rehabilitation. |
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Authors:
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S Rana; D Gupta; A Malik; R Katyal; S K Mehta |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 11 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 1995 May-Jun |
Date Detail:
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Created Date: 1996-02-09 Completed Date: 1996-02-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 292-5 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism,
physiology* Alkaline Phosphatase / analysis, physiology Animals Body Weight / physiology Carbon Radioisotopes Dietary Proteins / pharmacology Digestion Enteropeptidase / analysis, physiology Intestinal Absorption Intestine, Small / enzymology, metabolism, physiopathology* Macaca mulatta Male Microvilli / enzymology, metabolism, ultrastructure Proline / metabolism Protein-Energy Malnutrition / metabolism, physiopathology* Proteins / metabolism Xylose / blood |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Dietary Proteins; 0/Proteins; 0/Xylose; 147-85-3/Proline; EC 3.1.3.1/Alkaline Phosphatase; EC 3.4.21.9/Enteropeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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