| Mild to moderate kidney dysfunction and the risk of sudden cardiac death in the setting of acute myocardial infarction. | |
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MedLine Citation:
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PMID: 22079886 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Although end stage renal disease is known to elevate risk of sudden cardiac death (SCD), the role of less severe renal impairment in SCD is unclear. OBJECTIVE: To examine the association between mild-moderate renal impairment and first ischemic ventricular fibrillation. METHODS: Renal function in patients included in the Arrhythmia Genetics in the NEtherlands Study (AGNES) were compared. Cases (n=337, age: 56±1 yr, 80% men) were defined as patients who had survived VF at the time of their first acute ST elevation myocardial infarction (STEMI), and controls (n=339, age: 58±1 yr, 80% men) as those without VF during their first acute STEMI. Estimated glomerular filtration rate (eGFR) at the time of the acute STEMI was computed using the 4-variable Modification of Diet in Renal Disease equation. RESULTS: eGFR less than 105 ml/min, decrease in eGFR was associated with elevated odds of developing VF during STEMI. The association was essentially flat at eGFR levels greater than 105ml/min. The lowest eGFR quintile was associated with over a 6-fold increase in odds of developing VF compared to the fourth quintile. This association between eGFR and VF at the time of STEMI remained significant after adjusting for potential confounders including electrolyte levels. CONCLUSIONS: Mild to moderate kidney dysfunction is associated with a significantly elevated risk of VF in the setting of acute STEMI. Further studies should investigate the precise mechanisms by which mild kidney function results in VF. |
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Authors:
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Darshan Dalal; Jonas de Jong; Fleur V Y Tjong; Yaping Wang; Nienke Bruinsma; Lukas Dekker; Arthur A M Wilde |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-9 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: - ISSN: 1556-3871 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands; Department of Medicine (Cardiology), Johns Hopkins University, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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