Document Detail

Mild to moderate early exercise promotes recovery from cerebral ischemia in rats.
MedLine Citation:
PMID:  19650354     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We examined the effects of various exercise intensities on recovery from middle cerebral artery occlusion (MCAO) in rats. METHODS: First, we administered a 120-minute left MCAO to male Sprague-Dawley rats and randomly assigned them to one of four groups: no exercise (Group 1), mild exercise (Group 2), moderate exercise (Group 3), and severe exercise (Group 4). Then, we trained the rats for 30 min per day for one week or two weeks. We used a five-point neurological evaluation scale to measure neurological deficits 1-day, 4-days, 7-days, 10-days and 14-days after MCAO and measured infarct volume by use of 2% 2,3,4-triphenyltetrazolium chloride in exercised brains. We also performed immunohistochemistry analysis of the brain to observe reactive astrocytosis at the peri-infarct region. RESULTS: Neurological examination indicated that Group 2 and 3 recovered better than Group 1 after one week and two weeks (p < 0.05). Moreover, Group 2 and 3 had reduced brain infarct volume compared with Group 1 after one week (p < 0.05). There were no significant differences between Group 4 and Group 1. The thickness of the peri-infarct astrocytosis was significantly reduced in Group 4 relative to Group 1 after one week. There was a significant negative correlation between the extent of reactive astrocytosis and neurological recovery (r = -0.648, p < 0.01). CONCLUSION: This study demonstrates that mild to moderate exercise that begins soon after induced cerebral ischemia promotes recovery and that astrocytes may have an important role in the recovery process.
Shi-Uk Lee; Dae-Yul Kim; Sung-Hye Park; Deok-Hyung Choi; Hee-Won Park; Tai Ryoon Han
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  36     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  443-9     Citation Subset:  IM    
Department of Rehabilitation Medicine, Seoul National University Boramae Hospital, Sindaebang-Dong, Dongjak-Gu, Seoul.
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MeSH Terms
Brain Infarction / rehabilitation
Disease Models, Animal
Exercise Test
Exercise Therapy / methods*
Glial Fibrillary Acidic Protein / metabolism
Infarction, Middle Cerebral Artery / physiopathology*,  rehabilitation*
Neurologic Examination
Phosphopyruvate Hydratase / metabolism
Rats, Sprague-Dawley
Recovery of Function / physiology*
Severity of Illness Index
Statistics, Nonparametric
Time Factors
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; EC Hydratase

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