Document Detail


Mild-to-moderate COPD as a risk factor for increased 30-day mortality in cardiac surgery.
MedLine Citation:
PMID:  20922620     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is still a serious comorbidity in surgical procedures. We assessed the impact of mild to moderate COPD in a modern cardiac surgery unit.
METHODS: An age-, gender- and operation-matched cohort analysis of 242 patients treated between 01/2006 and 12/2008 was performed. COPD was defined as a FEV1 < 80 % and a FEV1/FVC ratio < 0.7 in preoperative spirometry. Primary end point was 30-day mortality.
RESULTS: Preoperative beta-agonist treatment of COPD patients was noted for 43 % of patients and not in the control group. After comparable surgery, postoperative respiratory failure was more frequent in COPD patients (10.4 % vs. 2.5 %, P = 0.02), whereas median ventilation time (12 h) and rate of reintubation (2.5 % vs. 3.5 %) did not significantly differ between both groups. Intensive care and hospital stay were significantly longer in the COPD group ( P = 0.02 and P = 0.04), and 30-day mortality was significantly higher in COPD patients (0.8 % vs. 6.1 %, P = 0.03).
CONCLUSIONS: COPD increases 30-day mortality, postoperative pulmonary complications, ICU stay and hospital stay. Proper identification and therapy may help to improve outcome in this high-risk population.
Authors:
M Ried; P Unger; T Puehler; A Haneya; C Schmid; C Diez
Publication Detail:
Type:  Journal Article     Date:  2010-10-04
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  58     ISSN:  1439-1902     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  387-91     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany. micha.ried@t-online.de
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / therapeutic use
Aged
Cardiac Surgical Procedures / adverse effects,  mortality*
Case-Control Studies
Chi-Square Distribution
Female
Forced Expiratory Volume
Germany
Humans
Intensive Care
Length of Stay
Logistic Models
Lung / physiopathology
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive / complications,  drug therapy,  mortality*,  physiopathology
Respiration, Artificial
Respiratory Insufficiency / etiology,  mortality,  therapy
Retrospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Spirometry
Time Factors
Treatment Outcome
Vital Capacity
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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