| Mild temperature hyperthermia and radiation therapy: role of tumour vascular thermotolerance and relevant physiological factors. | |
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MedLine Citation:
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PMID: 20210610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here we review the significance of changes in vascular thermotolerance on tumour physiology and the effects of multiple clinically relevant mild temperature hyperthermia (MTH) treatments on tumour oxygenation and corresponding radiation response. Thus far vascular thermotolerance referred to the observation of significantly greater blood flow response by the tumour to a second hyperthermia exposure than in response to a single thermal dose, even at temperatures that would normally cause vascular damage. New information suggests that although hyperthermia is a powerful modifier of tumour blood flow and oxygenation, sequencing and frequency are central parameters in the success of MTH enhancement of radiation therapy. We hypothesise that heat treatments every 2 to 3 days combined with traditional or accelerated radiation fractionation may be maximally effective in exploiting the improved perfusion and oxygenation induced by typical thermal doses given in the clinic. |
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Authors:
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Robert J Griffin; Ruud P M Dings; Azemat Jamshidi-Parsian; Chang W Song |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group Volume: 26 ISSN: 1464-5157 ISO Abbreviation: Int J Hyperthermia Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-07-22 Revised Date: 2011-06-17 |
Medline Journal Info:
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Nlm Unique ID: 8508395 Medline TA: Int J Hyperthermia Country: England |
Other Details:
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Languages: eng Pagination: 256-63 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72223, USA. rjgriffin@uams.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / physiopathology* Combined Modality Therapy Humans Hyperthermia, Induced* Mice Microcirculation Neoplasms / blood supply, physiopathology, radiotherapy* Radiation Tolerance |
| Grant Support | |
ID/Acronym/Agency:
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CA44114/CA/NCI NIH HHS; R01 CA044114-19/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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