| Mild systemic hypoxia and photopic visual field sensitivity. | |
| | |
MedLine Citation:
|
PMID: 20632996 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Purpose. Flickering stimuli increase the metabolic demand of the retina, making it a sensitive perimetric stimulus to the early onset of retinal disease. We determine whether flickering stimuli are a sensitive indicator of vision deficits resulting from acute, mild systemic hypoxia when compared to standard static perimetry. Methods. Static and flicker visual perimetry were performed in 14 healthy young participants while breathing 12% oxygen (hypoxia) under photopic illumination. The hypoxia visual field data were compared with the field data measured during normoxia. Absolute sensitivities (in dB) were analysed in seven concentric rings at 1°, 3°, 6°, 10°, 15°, 22° and 30° eccentricities as well as mean defect (MD) and pattern defect (PD) were calculated. Preliminary data are reported for mesopic light levels. Results. Under photopic illumination, flicker and static visual field sensitivities at all eccentricities were not significantly different between hypoxia and normoxia conditions. The mean defect and pattern defect were not significantly different for either test between the two oxygenation conditions. Conclusion. Although flicker stimulation increases cellular metabolism, flicker photopic visual field impairment is not detected during mild hypoxia. These findings contrast with electrophysiological flicker tests in young participants that show impairment at photopic illumination during the same levels of mild hypoxia. Potential mechanisms contributing to the difference between the visual fields and electrophysiological flicker tests including variability in perimetric data, neuronal adaptation and vascular autoregulation are considered. The data have implications for the use of visual perimetry in the detection of ischaemic/hypoxic retinal disorders under photopic and mesopic light levels. |
| | |
Authors:
|
Beatrix Feigl; Andrew J Zele; Ian B Stewart |
Related Documents
:
|
6280446 - An improved foot-shock titration procedure in rats for centrally acting analgesics. 9893306 - Pocket monster incident and low luminance visual stimuli: special reference to deep red... 12450496 - Circular contour frequency in shape discrimination. 7065106 - Spatial frequency thresholds versus border enhancement: sensitivity to retinal defocus. 20649126 - Quantifying the movement of multiple insects using an optical insect counter. 16005616 - Event-related brain potentials reveal multiple stages in the perceptual organization of... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta ophthalmologica Volume: 89 ISSN: 1755-3768 ISO Abbreviation: Acta Ophthalmol Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101468102 Medline TA: Acta Ophthalmol Country: England |
Other Details:
|
Languages: eng Pagination: e199-204 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. Journal compilation © 2010 Acta Ophthalmol. |
Affiliation:
|
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and se...
Next Document: Elevated levels of anti-endotoxin antibodies in patients with bilateral idiopathic acute anterior uv...