Document Detail

Mild serotonin syndrome on fluvoxamine.
MedLine Citation:
PMID:  11699328     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This preliminary study was performed to investigate the prevalence and severity of the serotonin-related symptoms for a group of patients in a clinical setting during fluvoxamine (FLU) using the Japanese version of the Serotonin Syndrome Scale (JSSS). METHODS: The subjects for the present study were 37 patients (20 and 17 patients with mood and anxiety disorders, respectively), meeting a diagnosis of DSM-IV. Each subject gave informed consent for the research involved in this study. Presence and severity of the serotonin-related symptoms were determined by Sternbach's criteria and the JSSS, respectively. RESULTS: (1) At the time of assessment, none of the patients fulfilled the diagnostic criteria of SS proposed by Sternbach, or none of the total JSSS scores of the patients was sufficient to reach the cutoff point of 7. (2) Sixteen of the 37 patients (43.2%) showed at least one symptom in the JSSS. (3) Spearman's rank correlations showed that there was a positive but nonsignificant correlation between the total JSSS scores and dosages of FLU. CONCLUSION: This preliminary study suggested that milder forms of the serotonin syndrome may exist for a group of patients in a clinical setting during FLU therapy.
Y Kaneda; Y Ishimoto; T Ohmori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  109     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-11-08     Completed Date:  2002-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
Department of Neuropsychiatry, University of Tokushima School of Medicine, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan.
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MeSH Terms
Dose-Response Relationship, Drug
Fluvoxamine / adverse effects*
Middle Aged
Mood Disorders / drug therapy*
Psychiatric Status Rating Scales
Serotonin Syndrome / chemically induced*,  diagnosis,  epidemiology
Serotonin Uptake Inhibitors / adverse effects*
Severity of Illness Index
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 54739-18-3/Fluvoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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