| Mild postischemic hypothermia is neuroprotective in the immature rat neocortex slice. | |
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MedLine Citation:
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PMID: 11251204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mild hypothermia as an intervention after perinatal asphyxia may prevent neurological damage in the newborn. We used stimulus-induced field potentials to monitor recovery from oxygen and glucose deprivation (OGD) in neocortex slices of 6-8-day-old wistar rats. OGD after a latency of 10.7+/-2.1 min (mean+/-S.E.) resulted in an anoxic depolarisation with an amplitude of 5.4+/-2.4 mV. Mild hypothermia of 31 degrees C (vs. 35 degrees C in the control group) was applied for 60 min after end of OGD. The 20, 40, 60 and 80% recovery of the field potential amplitude was significantly faster in the hypothermia group in comparison to the control group. These data indicate that mild postischemic hypothermia may have neuroprotective effects after perinatal asphyxia. |
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Authors:
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H Ko; M Zeller; S Gabriel; J Graulich; U Heinemann; M Obladen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research Volume: 894 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-19 Completed Date: 2001-06-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 297-300 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Charité Campus Virchow-Klinikum, Augustenburger Platz 1, D-13353, Berlin, Germany. hae-kyung.ko@rz.hu-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Body Temperature Brain Ischemia / physiopathology*, therapy* Female Glucose / pharmacology Hypothermia, Induced* Male Membrane Potentials / drug effects, physiology Neocortex / physiopathology* Organ Culture Techniques Oxygen / pharmacology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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