Document Detail


Mild parkinsonian signs and plasma homocysteine concentration in community-dwelling elderly individuals.
MedLine Citation:
PMID:  17998448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether plasma homocysteine (Hcy) concentration is associated with mild parkinsonian signs (MPS) in community-dwelling elderly individuals. DESIGN: Cross-sectional analyses of a population-based cohort study. SETTING: Washington Heights-Inwood, New York. Patients Persons without dementia 65 years and older. Main Outcome Measure Participants underwent an abbreviated motor portion of the Unified Parkinson's Disease Rating Scale. Each participant was assigned an MPS score (range, 0-40). The Hcy concentration was measured from plasma. All analyses were cross-sectional. RESULTS: There were 369 participants (mean +/- SD age, 77.8 +/- 6.0 years; mean +/- SD MPS score, 1.51 +/- 2.55; mean +/- SD plasma Hcy concentration, 17.3 +/- 6.5 mumol/L). Mean +/- SD MPS scores in plasma Hcy concentration quintiles were as follows: lowest quintile, 1.15 +/- 1.77; second quintile, 1.18 +/- 1.88; third quintile, 1.64 +/- 2.93; fourth quintile, 1.45 +/- 2.17; and highest quintile, 2.12 +/- 3.49 (84.3% higher than 1.15) (P = .02). In an unadjusted linear regression model, plasma Hcy concentration was associated with log MPS score (dependent variable) (P = .008). In a linear regression model that adjusted for confounding variables, plasma Hcy concentration was associated with log MPS score (P = .04). CONCLUSIONS: These data indicate that MPS are associated with higher plasma Hcy concentrations. Prospective neuroimaging as well as clinical-pathological studies would further our understanding of several mechanisms that could underlie the observed association.
Authors:
Elan D Louis; Nicole Schupf; Ming X Tang; Karen Marder; Jose A Luchsinger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of neurology     Volume:  64     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-13     Completed Date:  2008-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1646-51     Citation Subset:  AIM; IM    
Affiliation:
The Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA. EDL2@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cohort Studies
Community Health Planning
Cross-Sectional Studies
Dementia / blood*,  diagnosis,  epidemiology*,  etiology
Female
Geriatric Assessment
Homocysteine / blood*
Humans
Male
Mass Spectrometry / methods
Neurologic Examination
Neuropsychological Tests
Parkinsonian Disorders / blood*,  epidemiology*
Residence Characteristics*
Grant Support
ID/Acronym/Agency:
P01 AG07232/AG/NIA NIH HHS; R01 NS42859/NS/NINDS NIH HHS; RR00645/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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