Document Detail

Mild orotic aciduria and uricosuria in severe trauma victims.
MedLine Citation:
PMID:  1902349     Owner:  NLM     Status:  MEDLINE    
Hypermetabolic responses with respect to pyrimidine and purine kinetics in trauma victims were investigated during the catabolic phase before and after nutritional support. Orotic acid and uric acid excretions were measured in 32 adult, severely traumatized, hypermetabolic, and highly catabolic patients while they were receiving fluids with no calories or nitrogen. Patients were then fed intravenously amino acids and glucose or glucose alone or fed enterally for 5-6 d. Daily excretions of orotic acid, uric acid, urea, nitrogen, and creatinine were monitored. Mild orotic aciduria and uricosuria with hypouricemia were the basal-trauma responses. The significant (P = 0.001, r = 0.70) positive correlation between orotic and uric acid excretion demonstrates the parallelism between pyrimidine and purine metabolism. Feeding for 5-6 d could decrease but not readily abolish the injury-induced metabolic changes in nitrogen, pyrimidine, and purine metabolism. Glucose infusion alone may be sufficient to counteract the metabolic effects of trauma in the early flow phase of injury.
M Jeevanandam; Y C Hsu; L Ramias; W R Schiller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  53     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-24     Completed Date:  1991-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1242-8     Citation Subset:  AIM; IM    
Trauma Center, St Joseph's Hospital & Medical Center, Phoenix, AZ 85013.
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MeSH Terms
Amino Acids / administration & dosage,  therapeutic use
Creatinine / urine
Enteral Nutrition
Fluid Therapy
Glucose / administration & dosage,  therapeutic use
Middle Aged
Multiple Trauma / therapy,  urine*
Nitrogen / urine
Orotic Acid / urine*
Parenteral Nutrition
Purines / metabolism
Pyrimidines / metabolism
Trauma Severity Indices
Urea / urine
Uric Acid / urine*
Reg. No./Substance:
0/Amino Acids; 0/Purines; 0/Pyrimidines; 50-99-7/Glucose; 57-13-6/Urea; 60-27-5/Creatinine; 65-86-1/Orotic Acid; 69-93-2/Uric Acid; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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