Document Detail


Mild hypothermia reduces acute mortality and improves hemodynamic outcome in a cardiogenic shock pig model.
MedLine Citation:
PMID:  20627520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Cardiogenic shock is the main cause of death in patients hospitalized due to an acute myocardial infarction. Mild hypothermia reduces metabolism and could offer protective effects for this condition. The aim of our study was to investigate if mild therapeutic hypothermia would improve outcome and hemodynamic parameters in an ischemic cardiogenic shock pig model.
METHODS: Twenty-five pigs (40-50 kg) were anesthetized and a normothermic temperature of 38 degrees C was established utilising an endovascular cooling catheter in a closed-chest model. A Swan-Ganz catheter was placed in the pulmonary artery. Hemodynamic parameters were continuously monitored and blood gases were sampled every 30 min. Ischemia was induced by inflation of a PCI balloon in proximal LAD for 40 min. Sixteen pigs that have fulfilled predefined shock criteria were randomized to hypothermia (n=8), or normothermia (n=8). Hypothermia (33 degrees C) was induced after onset of reperfusion by using an endovascular temperature modulating catheter and was maintained until termination of the experiment.
RESULTS: The pigs in the hypothermia group were cooled to <34 degrees C in approximately 45 min. 5/8 pigs in the normothermia group died while all pigs in the hypothermia group survived (p<0.01). Stroke volume and blood pressure were significantly higher in the hypothermia group (p<0.05), whereas heart rate was significantly lower in the hypothermia group (p=0.01). Cardiac output did not differ among the groups (p=0.13). Blood gas analysis revealed higher mixed venous oxygen saturation, pH, and base excess in the hypothermia group indicating less development of metabolic acidosis (p<0.05).
CONCLUSIONS: In this pig model, mild therapeutic hypothermia reduces acute mortality in cardiogenic shock, improves hemodynamic parameters and reduces metabolic acidosis. These findings suggest a possible clinical benefit of therapeutic hypothermia for patients with acute cardiogenic shock.
Authors:
Matthias Götberg; Jesper van der Pals; Göran K Olivecrona; Michael Götberg; Sasha Koul; David Erlinge
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-02
Journal Detail:
Title:  Resuscitation     Volume:  81     ISSN:  1873-1570     ISO Abbreviation:  Resuscitation     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1190-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Dept. of Coronary Heart Disease, Skane University Hospital, Lund University, S-22185, Lund, Sweden. matthias.gotberg@med.lu.se
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MeSH Terms
Descriptor/Qualifier:
Acidosis / etiology,  physiopathology
Animals
Arrhythmias, Cardiac / etiology
Blood Circulation
Body Temperature
Female
Gases / blood
Hemodynamics*
Hypothermia, Induced*
Kaplan-Meier Estimate
Male
Myocardial Infarction / complications*
Myocardial Ischemia / complications,  therapy
Myocardial Reperfusion
Severity of Illness Index
Shock, Cardiogenic / etiology*,  mortality*,  physiopathology,  therapy*
Time Factors
Chemical
Reg. No./Substance:
0/Gases

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