| Mild hypothermia protects against sodium taurocholate (NaTc)-induced acute pancreatitis in rats with adverse effects on serum cytokines. | |
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MedLine Citation:
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PMID: 15841032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To test the effect of mild hypothermia in reducing pancreatic damage and improving the survival of acute hemorrhagic and necrotic pancreatitis (AHNP) in rats. METHODS: Thirty-six male Sprague-Dawley rats were studied. Sham animals (n = 12) received laparotomy and normothermia; for AHNP with normothermia (n = 12), the core temperature was maintained at 37 degrees C to 37.5 degrees C after AHNP for 2 to 5 hours; for AHNP with hypothermia (n = 12), the core temperature was maintained at 32 degrees C to 33 degrees C afterward. Serum amylase and lipase, interleukin (IL)-1beta, and tumor necrosis factor (TNF-alpha) were measured. The pancreas was examined histologically. In a separate experiment, the core temperature was kept either in normothermia (n = 20) or mild hypothermia (n = 20) for 12 hours after the induction of AHNP; the animals were then returned to their cage. The survival rate was monitored up to 72 hours. RESULTS: Mild hypothermia significantly decreased the release of serum amylase and lipase compared with AHNP normothermia at 2 and 5 hours. Histology examination revealed significantly less tissue damage in AHNP hypothermia. There was a further increase in TNF-alpha and IL-1beta in AHNP in animals with hypothermia compared with normothermia animals. The application of mild hypothermia significantly improved the survival in animals induced with AHNP. CONCLUSIONS: Mild hypothermia decreases amylase and lipase release and improves a survival of AHNP in rats. |
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Authors:
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XueMin Wang; Wei Jiang; Gang Zhao; DongPing Du; Ming Zhou; YanNan Hang; Chuanyao Tong |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 30 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-20 Completed Date: 2006-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: e80-6 Citation Subset: IM |
Affiliation:
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Department of Intensive Care Unit, Shanghai 6th Municipal Hospital, Medical College of Shanghai Jiao Tong University, Shanghai, China. wangxm@sjtu.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Amylases / blood Animals Cholagogues and Choleretics Edema / chemically induced, immunology, prevention & control Hypothermia, Induced* Interleukin-1 / blood* Lipase / blood Male Organ Size Pancreas / pathology Pancreatitis, Acute Necrotizing / chemically induced, immunology*, therapy* Rats Rats, Sprague-Dawley Severity of Illness Index Survival Rate Taurocholic Acid Tumor Necrosis Factor-alpha / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cholagogues and Choleretics; 0/Interleukin-1; 0/Tumor Necrosis Factor-alpha; 81-24-3/Taurocholic Acid; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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