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Mild hypothermia attenuates changes in respiratory system mechanics and modifies cytokine concentration in bronchoalveolar lavage fluid during low lung volume ventilation.
MedLine Citation:
PMID:  20533858     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hypothermia was shown to attenuate ventilator-induced lung injury due to large tidal volumes. It is unclear if the protective effect of hypothermia is maintained under less injurious mechanical ventilation in animals without previous lung injury. Tracheostomized rats were randomly allocated to non-ventilated group (group C) or ventilated groups of normothermia (group N) and mild hypothermia (group H). After two hours of mechanical ventilation with inspiratory fraction of oxygen 1.0, respiratory rate 60 min(-1), tidal volume 10 ml·kg(-1), positive end-expiratory pressure (PEEP) 2 cm H(2)O or immediately after tracheostomy in non-ventilated animals inspiratory pressures were recorded, rats were sacrificed, pressure-volume (PV) curve of respiratory system constructed, bronchoalveolar lavage (BAL) fluid and aortic blood samples obtained. Group N animals exhibited a higher rise in peak inspiratory pressures in comparison to group H animals. Shift of the PV curve to right, higher total protein and interleukin-6 levels in BAL fluid were observed in normothermia animals in comparison with hypothermia animals and non-ventilated controls. Tumor necrosis factor-alpha was lower in the hypothermia group in comparison with normothermia and non-ventilated groups. Mild hypothermia attenuated changes in respiratory system mechanics and modified cytokine concentration in bronchoalveolar lavage fluid during low lung volume ventilation in animals without previous lung injury.
Authors:
P Dostál; M Senkeřík; R Pařízková; D Bareš; P Zivný; H Zivná; V Cerný
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Publication Detail:
Type:  Journal Article     Date:  2010-06-09
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  59     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  937-44     Citation Subset:  IM    
Affiliation:
Department of Anesthesia and Intensive Care, University Hospital Hradec Králové, Hradec Králové, Czech Republic. dostal@fnhk.cz.
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