Document Detail


Mild endotoxaemia and the inflammatory response induced by a marathon race.
MedLine Citation:
PMID:  9176042     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. To address the question of whether endotoxaemia could be involved in the inflammatory response induced by long-term strenuous exercise, 18 male marathon runners [mean age 41 +/- 2 (SEM) years] were studied. Their performance in the marathon ranged from 2 h 46 min to 4 h 42 min. 2. Four venous blood samples were drawn: at rest, just before the race (baseline); within 15 min following the completion of the marathon; after 1 h of recovery; and the morning after the race. 3. The following humoral markers of the inflammatory response to exercise were measured: polymorphonuclear myeloperoxidase (MPO), anaphylatoxin C5a (C5a), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Plasma endotoxin was measured by a sensitive and rapid chromogenic Limulus assay. All inflammatory markers were significantly increased (P < 0.001) after the race, reaching in most cases peak values in the first blood sample drawn following the completion of the marathon [MPO, 298 +/- 19 ng/ml (SEM); C5a, 1.45 +/- 0.32 ng/ml; TNF-alpha, 20 +/- 3 pg/ml; IL-6, 88 +/- 13 pg/ml] when compared with baseline [MPO, 146 +/- 16 ng/ml (SEM); C5a, 0.27 +/- 0.2 ng/ml; TNF-alpha, 12 +/- 1.5 pg/ml: IL-6, 1.0 +/- 0.5 pg/ml]. Traces of plasma endotoxin (ranging from 5 to 13 pg/ml, with one exceptionally high value of 72 pg/ml measured in one runner) were detected in seven subjects within the first hour of recovery. An ELISA method was used to determine the endogenous IgG antibodies toward a range of Gram-negative bacterial lipopolysaccharides (LPSs) of different sizes and structures. A transient decrease in certain anti-LPS activities, mainly against rough LPS, occurred in most cases in the first blood sample drawn after the race. There was no correlation between the magnitude of the inflammatory response to exercise, as assessed by the increase in blood levels of humoral markers of inflammation, and the changes in circulating endotoxin levels of anti-LPS IgG activity following the race. 4. From these results, we conclude that the mild, transient endotoxaemia detected in some of our subjects does not play a major role in the observed inflammatory response to a marathon competition.
Authors:
G Camus; J Poortmans; M Nys; G Deby-Dupont; J Duchateau; C Deby; M Lamy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  92     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-20     Completed Date:  1997-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  415-22     Citation Subset:  IM    
Affiliation:
Center for the Biochemistry of Oxygen, Institute of Chemistry, University of Liège, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies / blood
Biological Markers / blood
Complement C5a / analysis
Endotoxemia / blood,  etiology*,  immunology
Humans
Immunoglobulin G / blood
Interleukin-6 / analysis
Lipopolysaccharides / immunology
Male
Middle Aged
Peroxidase / blood
Physical Endurance*
Running*
Systemic Inflammatory Response Syndrome / blood,  etiology,  immunology
Tumor Necrosis Factor-alpha / analysis
Chemical
Reg. No./Substance:
0/Antibodies; 0/Biological Markers; 0/Immunoglobulin G; 0/Interleukin-6; 0/Lipopolysaccharides; 0/Tumor Necrosis Factor-alpha; 80295-54-1/Complement C5a; EC 1.11.1.7/Peroxidase

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