| Mild cold exposure increases survival in rats with medial preoptic lesions. | |
| | |
MedLine Citation:
|
PMID: 7367860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High mortality rate in rats with large medial preoptic lesions discourage their use in studies of brain function. However, virtually all such animals (six out of seven) survived indefinitely if kept at an ambient temperature of 15 degrees C for 2 hours before and 10 to 12 hours after the lesions were made. Although these rats appeared otherwise healthy, they could not maintain normal both temperatures in short-term cold tests. In contrast, five of the nine rats kept at 25 degrees C died within 10 hours after the operation, and three more died within 5 days. Rats kept at 25 degrees C had a much higher incidence of cardiac arrhythmias than did rats kept at 15 degrees C, which may be responsible for their higher moratlity rates. |
| | |
Authors:
|
J A Nagel; E Satinoff |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Science (New York, N.Y.) Volume: 208 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1980 Apr |
Date Detail:
|
Created Date: 1980-06-25 Completed Date: 1980-06-25 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 301-3 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Temperature Regulation* Brain / physiology Cold Temperature* Female Heart Rate Hypothalamus / physiology* Male Motor Activity / physiology Oxygen Consumption Preoptic Area / physiology*, surgery Rats Vasoconstriction |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic expression of Wilson's disease in cell culture: a diagnostic marker.
Next Document: Cadmium increases tissue factor (coagulation factor III) activity by facilitating its reassociation ...