| Mild cognitive impairment: to treat or not to treat. | |
| | |
MedLine Citation:
|
PMID: 16263056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mild cognitive impairment (MCI) refers to memory deficits in excess of normal aging, but not sufficient for the diagnosis of Alzheimer's disease (AD). In general, patients with MCI are not disabled and have no other obvious cognitive deficits other than memory. Many studies have shown that patients with MCI are more likely to progress to AD than age-matched controls. Drug therapy to prevent or delay deterioration in patients with MCI has been tested only very recently. The results of three clinical trials are discussed. One of two trials with donepizil suggests that donepizil may delay onset of AD, but the effect is modest and the side effects are problematic. Galantamine appeared to be associated with excess deaths, and vitamin E was not effective. No medications are currently indicated for the prevention of dementia in patients with MCI. |
| | |
Authors:
|
Howard S Kirshner |
Related Documents
:
|
21073136 - A delayed recall battery as a sensitive screening for mild cognitive impairment: follow... 8722896 - Comparative study of oral and written picture description in patients with alzheimer's ... 20625166 - Head circumference, atrophy, and cognition: implications for brain reserve in alzheimer... 23549756 - Synaptic plasticity in cephalopods; more than just learning and memory? 12456876 - Attentional mechanisms of borderline personality disorder. 21584676 - Time in action contexts: learning when an action effect occurs. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current neurology and neuroscience reports Volume: 5 ISSN: 1528-4042 ISO Abbreviation: Curr Neurol Neurosci Rep Publication Date: 2005 Nov |
Date Detail:
|
Created Date: 2005-11-02 Completed Date: 2006-04-12 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100931790 Medline TA: Curr Neurol Neurosci Rep Country: United States |
Other Details:
|
Languages: eng Pagination: 455-7 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Stroke Division, Vanderbilt University School of Medicine, 2100 Pierce Avenue, MCS 320, Nashville, TN 37232, USA. Howard.Kirshner@vanderbilt.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
complications Cholinesterase Inhibitors / therapeutic use* Clinical Trials as Topic Cognition Disorders / drug therapy*, etiology Disease Progression Humans Indans / therapeutic use* Piperidines / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Cholinesterase Inhibitors; 0/Indans; 0/Piperidines; 120011-70-3/donepezil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Central nervous system Lyme disease.
Next Document: Aphasia and right hemisphere syndromes in stroke.