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MedLine Citation:
PMID:  22677346     Owner:  NLM     Status:  Publisher    
ABSTRACT INTRODUCTION:Cognitive impairment is a frequent feature of chronic obstructive pulmonary disease (COPD). However, the proportion of COPD patients with mild cognitive impairment (MCI) is still unknown, and no screening test has been validated to date for detecting MCI in this population. OBJECTIVE:To determine the frequency and subtypes of MCI in COPD patients and to assess the validity of two cognitive screening tests, the Mini-Mental State Examination (MMSE), and the Montreal Cognitive Assessment (MoCA), in detecting MCI in COPD. METHODS:Forty-five moderate to severe COPD patients and 50 healthy controls underwent a comprehensive neuropsychological assessment using standard MCI criteria. Receiver operating characteristic curves were obtained to assess the validity of the MMSE and the MoCA to detect MCI in COPD patients. RESULTS:MCI was found in 36% of COPD patients compared to 12% of healthy subjects. COPD patients with MCI had mainly the nonamnestic MCI single domain subtype with predominant attention and executive dysfunctions. The optimal MoCA screening cut-off was 26 (≤25 indicates impairment, with 81% sensitivity, 72% specificity and 76% correctly diagnosed). No MMSE cut-off had acceptable validity. CONCLUSIONS:In this preliminary study, a substantial proportion of COPD patients were found to have MCI, a known risk factor for dementia. Longitudinal follow-up on these patients is needed to determine the risk of developing more severe cognitive and functional impairments. Moreover, the MoCA is superior to the MMSE in detecting MCI in COPD patients.
Sylvia Villeneuve; Véronique Pépin; Shady Rahayel; Josie-Anne Bertrand; Myriam Delorimier; Amanda Rizk; Catherine Desjardins; Simon Parenteau; François Beaucage; Steve Joncas; Oury Monchi; Jean-François Gagnon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-7
Journal Detail:
Title:  Chest     Volume:  -     ISSN:  1931-3543     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Département de psychologie, Université de Montréal, QC, Canada.
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