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Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism.
MedLine Citation:
PMID:  21940621     Owner:  NLM     Status:  Publisher    
OBJECTIVE:To characterize brain metabolic changes associated with mild cognitive impairment (MCI) in drug-naive patients with Parkinson disease (PD) using (18)F-fluorodeoxyglucose (FDG) and PET (FDG-PET). METHODS:This cross-sectional study included newly diagnosed patients with PD with MCI in single or multiple domain (PD-MCI; n = 12) and without MCI (PD-nMCI; n = 12), and healthy controls (n = 12). The groups were matched for age. Moreover, the patient groups were matched for motor disability. All subjects underwent a FDG-PET study. Cerebral regional relative metabolic maps were compared in PD-MCI, PD-nMCI, and controls using regions of interest analysis (ROIs) and voxel-based analysis with statistical parametric mapping. RESULTS:ROIs and voxel-based analyses revealed significant relative hypometabolism in the prefrontal, superior/inferior parietal, and associative occipital cortices as well as in the striatum in patients with PD-MCI relative to controls (p < 0.05) and to a lesser extent in patients with PD-nMCI. In contrast, patients with PD-nMCI did not show significant metabolic changes as compared to controls. CONCLUSION:MCI in patients with PD is associated with cortical hypometabolism since the earliest stage, independent of therapy or motor disability. The early involvement of posterior cortical region, a pattern shared by advanced stages of PD-MCI and PD with dementia, could represent an early marker of dementia. The relevance of this pattern in predicting prodromal dementia has to be evaluated in longitudinal studies.
S Pappatà; G Santangelo; D Aarsland; C Vicidomini; K Longo; K Bronnick; M Amboni; R Erro; C Vitale; M G Caprio; M T Pellecchia; A Brunetti; G De Michele; M Salvatore; P Barone
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-21
Journal Detail:
Title:  Neurology     Volume:  -     ISSN:  1526-632X     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Institute of Biostructure and Bioimaging (S.P., C.V., A.B., M.S.), CNR, Naples; Department of Psychology (G.S.), Second University of Naples, Caserta; IDC Hermitage Capodimonte (G.S., K.L., M.A., C.V., P.B.), Naples; Departments of Neurological Sciences (G.S., K.L., M.A., R.E., M.T.P., G.D., P.B.) and Biomorphological Sciences (M.G.C., A.B., M.S.), University "Federico II," Naples, Italy; Psychiatric Division (D.A., K.B.), Stavanger University Hospital, Stavanger, and University of Oslo, Oslo, Norway; University "Parthenope" (C.V.), Naples; and Centro Regionale Campano per la Malattia di Parkinson e Disturbi del Movimento (P.B.), Schola Medica Salernitana, University of Salerno, Italy.
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