Document Detail

Mild cognitive impairment in Parkinson's disease is associated with a distributed pattern of brain white matter damage.
MedLine Citation:
PMID:  23843285     Owner:  NLM     Status:  Publisher    
This study assesses the patterns of gray matter (GM) and white matter (WM) damage in patients with Parkinson's disease and mild cognitive impairment (PD-MCI) compared with healthy controls and cognitively unimpaired PD patients (PD-Cu). Three-dimensional T1-weighted and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were obtained from 43 PD patients and 33 healthy controls. Cognition was assessed using a neuropsychological battery. Tract-based spatial statistics was applied to compare DT MRI indices between groups on a voxel-by-voxel basis. Voxel-based morphometry was performed to assess GM atrophy. Thirty PD patients were classified as MCI. Compared with healthy controls, PD-Cu and PD-MCI patients did not have GM atrophy. No region of WM damage was found in PD-Cu patients when compared with healthy controls. Relative to healthy controls and PD-Cu patients, PD-MCI patients showed a distributed pattern of WM abnormalities in the anterior and superior corona radiata, genu, and body of the corpus callosum, and anterior inferior fronto-occipital, uncinate, and superior longitudinal fasciculi, bilaterally. Subtle cognitive decline in PD is associated with abnormalities of frontal and interhemispheric WM connections, and not with GM atrophy. DT MRI might contribute to the identification of structural changes in PD-MCI patients prior to the development of dementia. Hum Brain Mapp, 2013. © 2013 Wiley Periodicals, Inc.
Federica Agosta; Elisa Canu; Elka Stefanova; Lidia Sarro; Aleksandra Tomić; Vladana Spica; Giancarlo Comi; Vladimir S Kostić; Massimo Filippi
Related Documents :
23996715 - The effect of polymorphisms of beta2 adrenoceptors on response to long-acting beta2 ago...
24283945 - Detection of bleeding disorders in lebanon: outcomes of a pilot programme.
24278225 - Nitrotyrosine level was associated with mortality in patients with acute kidney injury.
25101485 - Electrogram morphology recurrence patterns during atrial fibrillation.
9580755 - Uncertainty in the diagnosis of cystic fibrosis: possible role of in vivo nasal potenti...
2123635 - Longitudinal survey of apolipoproteins and atherogenic risk in hemodialysis and continu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-11
Journal Detail:
Title:  Human brain mapping     Volume:  -     ISSN:  1097-0193     ISO Abbreviation:  Hum Brain Mapp     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9419065     Medline TA:  Hum Brain Mapp     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  6-Methyl 3-chromonyl 2,4-thiazolidinedione/2,4-imidazolidinedione/2-thioxo-imidazolidine-4-one compo...
Next Document:  Cyplecksins Are Covalent Inhibitors of the Pleckstrin Homology Domain of Cytohesin.