| Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis. | |
| | |
MedLine Citation:
|
PMID: 20855849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: In studies of mild cognitive impairment (MCI) in Parkinson disease (PD), patients without dementia have reported variable prevalences and profiles of MCI, likely to be due to methodologic differences between the studies. OBJECTIVE: The objective of this study was to determine frequency and the profile of MCI in a large, multicenter cohort of well-defined patients with PD using a standardized analytic method and a common definition of MCI. METHODS: A total of 1,346 patients with PD from 8 different cohorts were included. Standardized analysis of verbal memory, visuospatial, and attentional/executive abilities was performed. Subjects were classified as having MCI if their age- and education-corrected z score on one or more cognitive domains was at least 1.5 standard deviations below the mean of either control subjects or normative data. RESULTS: A total of 25.8% of subjects (95% confidence interval [CI] 23.5-28.2) were classified as having MCI. Memory impairment was most common (13.3%; 11.6-15.3), followed by visuospatial (11.0%; 9.4-13.0) and attention/executive ability impairment (10.1%; 8.6-11.9). Regarding cognitive profiles, 11.3% (9.7-13.1) were classified as nonamnestic single-domain MCI, 8.9% (7.0-9.9) as amnestic single-domain, 4.8% (3.8-6.1) as amnestic multiple-domain, and 1.3% (0.9-2.1) as nonamnestic multiple-domain MCI. Having MCI was associated with older age at assessment and at disease onset, male gender, depression, more severe motor symptoms, and advanced disease stage. CONCLUSIONS: MCI is common in patients with PD without dementia, affecting a range of cognitive domains, including memory, visual-spatial, and attention/executive abilities. Future studies of patients with PD with MCI need to determine risk factors for ongoing cognitive decline and assess interventions at a predementia stage. |
| | |
Authors:
|
D Aarsland; K Bronnick; C Williams-Gray; D Weintraub; K Marder; J Kulisevsky; D Burn; P Barone; J Pagonabarraga; L Allcock; G Santangelo; T Foltynie; C Janvin; J P Larsen; R A Barker; M Emre |
Related Documents
:
|
20119649 - Sharpening the boundaries of parkinson-associated dementia: recommendation for a neurop... 12907179 - The relationship between executive function and verbal memory in parkinson's disease. 3687379 - The adverse effect of benzhexol on memory in parkinson's disease. 10950919 - The contribution of apraxic speech to working memory deficits in parkinson's disease. 20629139 - Decision making in de novo parkinson's disease. 18602449 - Time estimation in healthy ageing and neurodegenerative basal ganglia disorders. 18437279 - Anterior hippocampus orchestrates successful encoding and retrieval of non-relational m... 18300719 - Selective impairment of cognitive performance in the young monkey following recovery fr... 17378229 - The utility of the mini-mental status exam in older adults with traumatic brain injury. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neurology Volume: 75 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-21 Completed Date: 2010-10-08 Revised Date: 2012-11-26 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
|
Languages: eng Pagination: 1062-9 Citation Subset: AIM; IM |
Affiliation:
|
Stavanger University Hospital, Psychiatric Division, PO Box 8100, 4068 Stavanger, Norway. daarsland@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Chi-Square Distribution Cognition Disorders / complications*, diagnosis, epidemiology* Female Humans Logistic Models Male Memory Disorders / complications*, diagnosis Neuropsychological Tests Parkinson Disease / complications* Patient Selection Prevalence |
| Grant Support | |
ID/Acronym/Agency:
|
K23 MH067894/MH/NIMH NIH HHS; K23 MH067894-05/MH/NIMH NIH HHS |
| Comments/Corrections | |
Comment In:
|
Evid Based Ment Health. 2011 Feb;14(1):5
[PMID:
21266602
]
Neurology. 2010 Sep 21;75(12):1038-9 [PMID: 20855847 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diffusion tensor imaging, permanent pyramidal tract damage, and outcome in subcortical stroke.
Next Document: 3-Methylglutaconic aciduria type I redefined: A syndrome with late-onset leukoencephalopathy.