Document Detail

Mild cognitive impairment and alzheimer disease: patterns of altered cerebral blood flow at MR imaging.
MedLine Citation:
PMID:  19164119     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine regional cerebral blood flow (rCBF) in incident mild cognitive impairment (MCI) and Alzheimer disease (AD) by using continuous arterial spin-labeling (CASL) magnetic resonance (MR) imaging.
MATERIALS AND METHODS: This study was approved by the local institutional review board and was compliant with HIPAA regulations. Informed consent was obtained. rCBF was measured in 38 control subjects, 29 MCI patients, and 37 AD patients who were participating in a longitudinal epidemiologic study. Multisection CASL MR imaging with alternating single and double adiabatic inversion pulses and ramp-sampled echo-planar imaging were performed to acquire 19 contiguous axial sections. Voxel-level rCBF was compared among groups by using an analysis of variance design; clusters of voxels with significant group differences were identified. Multiple regression models controlled for age, sex, and presence of hypertension and related the mean rCBF in those clusters to the presence of MCI and AD.
RESULTS: MCI and AD patients had decreased rCBF in the posterior cingulate gyrus (P = .01) with extension to the medial precuneus compared with that in control subjects. MCI patients had increased rCBF in the left hippocampus (P < .001), right amygdala (P = .007), and rostral head of the right caudate nucleus and ventral putamen and globus pallidus (P = .003) compared with that in control subjects. AD patients had decreased rCBF relative to that in control subjects and MCI patients in the left inferior parietal (P = .005), left lateral frontal (P < .001), left superior temporal (P = .001), and left orbitofrontal (P = .003) cortices. AD patients had increased rCBF in the right anterior cingulate gyrus (P = .02) compared with that in control subjects.
CONCLUSION: The transition from normal cognition to AD is associated with dynamic pathologic processes in the brain, and this is reflected by both decreases and increases in rCBF. Increases in rCBF suggest a cellular and vascular compensatory process associated with incipient AD.
Weiying Dai; Oscar L Lopez; Owen T Carmichael; James T Becker; Lewis H Kuller; H Michael Gach
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Publication Detail:
Type:  Journal Article     Date:  2009-01-21
Journal Detail:
Title:  Radiology     Volume:  250     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-26     Completed Date:  2009-04-01     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  856-66     Citation Subset:  AIM; IM    
Copyright Information:
RSNA, 2009
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / complications*,  diagnosis*
Brain / blood supply*
Cerebrovascular Circulation*
Cognition Disorders / complications*,  diagnosis*
Magnetic Resonance Imaging / methods*
Grant Support
K01 AG030514/AG/NIA NIH HHS; K01 AG030514-01A1/AG/NIA NIH HHS; P30 AG010129/AG/NIA NIH HHS; P30 AG010129-19/AG/NIA NIH HHS; R56 AG020098/AG/NIA NIH HHS; R56 AG020098-06A1/AG/NIA NIH HHS
Comment In:
Radiology. 2011 Nov;261(2):664-5   [PMID:  22012913 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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