Document Detail


Mild traumatic brain injury: longitudinal regional brain volume changes.
MedLine Citation:
PMID:  23481161     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate longitudinal changes in global and regional brain volume in patients 1 year after mild traumatic brain injury (MTBI) and to correlate such changes with clinical and neurocognitive metrics.
MATERIALS AND METHODS: This institutional review board-approved study was HIPAA compliant. Twenty-eight patients with MTBI (with 19 followed up at 1 year) with posttraumatic symptoms after injury and 22 matched control subjects (with 12 followed up at 1 year) were enrolled. Automated segmentation of brain regions to compute regional gray matter (GM) and white matter (WM) volumes was performed by using three-dimensional T1-weighted 3.0-T magnetic resonance imaging, and results were correlated with clinical metrics. Pearson and Spearman rank correlation coefficients were computed between longitudinal brain volume and neurocognitive scores, as well as clinical metrics, over the course of the follow-up period.
RESULTS: One year after MTBI, there was measurable global brain atrophy, larger than that in control subjects. The anterior cingulate WM bilaterally and the left cingulate gyrus isthmus WM, as well as the right precuneal GM, showed significant decreases in regional volume in patients with MTBI over the 1st year after injury (corrected P < .05); this was confirmed by means of cross-sectional comparison with data in control subjects (corrected P < .05). Left and right rostral anterior cingulum WM volume loss correlated with changes in neurocognitive measures of memory (r = 0.65, P = .005) and attention (r = 0.60, P = .01). At 1-year follow-up, WM volume in the left cingulate gyrus isthmus correlated with clinical scores of anxiety (Spearman rank correlation r = -0.68, P = .007) and postconcussive symptoms (Spearman rank correlation r = -0.65, P = .01).
CONCLUSION: These observations demonstrate structural changes to the brain 1 year after injury after a single concussive episode. Regional brain atrophy is not exclusive to moderate and severe traumatic brain injury but may be seen after mild injury. In particular, the anterior part of the cingulum and the cingulate gyrus isthmus, as well as the precuneal GM, may be distinctively vulnerable 1 year after MTBI.
Authors:
Yongxia Zhou; Andrea Kierans; Damon Kenul; Yulin Ge; Joseph Rath; Joseph Reaume; Robert I Grossman; Yvonne W Lui
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-03-12
Journal Detail:
Title:  Radiology     Volume:  267     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-24     Completed Date:  2013-08-09     Revised Date:  2014-06-11    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  880-90     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Atrophy
Brain Injuries / pathology*
Case-Control Studies
Female
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Organ Size
Time Factors
Grant Support
ID/Acronym/Agency:
5UL1RR029893/RR/NCRR NIH HHS; R01 NS039135/NS/NINDS NIH HHS; R01 NS039135-10/NS/NINDS NIH HHS; UL1 TR000038/TR/NCATS NIH HHS
Comments/Corrections
Comment In:
Radiology. 2013 Aug;268(2):611-2   [PMID:  23882101 ]
Radiology. 2013 Aug;268(2):612   [PMID:  24044126 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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