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Mild Rhodium(III)-Catalyzed C-H Activation and Annulation with Alkyne MIDA Boronates: Short and Efficient Synthesis of Heterocyclic Boronic Acid Derivatives.
MedLine Citation:
PMID:  23146122     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Taking advantage of Rh(III)-catalyzed C-H activation reactions, we have developed a mild, short and efficient method for the synthesis of bench-stable 3-isoquinolone MIDA boronates. The reaction is practical and scalable. The product formed has been applied in the Suzuki-Miyaura reaction with high efficiency. This strategy has also been successfully expanded to the synthesis of MIDA boronate functionalized heterocycles such as isoquinoline, pyrrole and indole.
Authors:
Honggen Wang; Christoph Grohmann; Corinna Nimphius; Frank Glorius
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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