| Mild Mitochondrial Uncoupling as a Therapeutic Strategy. | |
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MedLine Citation:
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PMID: 21275885 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mild mitochondrial uncoupling, or the reduction of the efficiency of energy conversion without compromising intracellular high energy phosphate levels, is a protective therapeutic strategy under many laboratory conditions. Here we discuss these conditions, which include both cell and animal models of ischemia reperfusion and complications associated with the metabolic syndrome. We also discuss drugs that promote mild mitochondrial uncoupling and naturally occurring mild mitochondrial uncoupling pathways involving free fatty acid cycling and K(+) transport. |
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Authors:
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Fernanda M Cunha; Camille C Caldeira da Silva; Fernanda M Cerqueira; Alicia J Kowaltowski |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-26 |
Journal Detail:
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Title: Current drug targets Volume: - ISSN: 1873-5592 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil. alicia@iq.usp.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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