| The Mikamo lecture. Tomographic assessment of myocardial perfusion and metabolism in the evaluation of coronary thrombolysis. | |
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MedLine Citation:
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PMID: 3108555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although coronary thrombolysis with fibrinolytic agents leads to restoration of patency of coronary arteries demonstratable angiographically, elucidation of the efficacy of the approach requires evaluation of its effect on the heart. Clot-selective fibrinolytic agents such as tissue-type plasminogen activator (t-PA) offer particular promise as therapeutic agents because they induce clot lysis without marked activation of the fibrinolytic system in the circulating blood and hence without marked fibrinogenolysis and predisposition to bleeding. Results of several large scale clinical trials demonstrate recanalization in approximately 75% of patients. Detection of recanalization may be achievable by analysis of plasma creatine kinase isoforms as a function of time, and in the research environment, with the use of positron emission tomography. This modality demonstrates restoration of regional perfusion and intermediary myocardial metabolism and provides an approach for calibration of conventional and more widely applicable diagnostic procedures such as scintigraphy. |
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Authors:
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B E Sobel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Japanese circulation journal Volume: 51 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1987 Jan |
Date Detail:
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Created Date: 1987-07-08 Completed Date: 1987-07-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemotherapy, Cancer, Regional Perfusion Coronary Angiography Coronary Circulation Coronary Disease / drug therapy* Fibrinolytic Agents / therapeutic use* Humans Tissue Plasminogen Activator / therapeutic use Tomography, Emission-Computed |
| Grant Support | |
ID/Acronym/Agency:
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HL 17646/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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