| Migratory pulmonary infiltrates in a patient with rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 11978928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The case history is described of an elderly man with rheumatoid arthritis receiving treatment with sulfasalazine and the cyclooxygenase-2 inhibitor celecoxib who presented with severe shortness of breath, cough, and decreased exercise tolerance. The chest radiograph showed unilateral alveolo-interstitial infiltrates and a biopsy specimen of the lung parenchyma showed changes consistent with acute eosinophilic pneumonia. Antibiotic treatment was unsuccessful, but treatment with steroids and discontinuation of sulfasalazine and celecoxib resulted in a marked clinical improvement confirmed by arterial blood gas analysis. The condition may have developed as an adverse reaction either to sulfasalazine or to celecoxib, although hypersensitivity to the latter has not previously been reported. |
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Authors:
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S Mehandru; R L Smith; G S Sidhu; N Cassai; C P Aranda |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Thorax Volume: 57 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-04-29 Completed Date: 2002-06-13 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
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Languages: eng Pagination: 465-7 Citation Subset: IM |
Affiliation:
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Departments of Medicine and Pathology, School of Medicine, New York University, New York, USA. saurabh_13@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Airway Obstruction / chemically induced, pathology*, radiography Antirheumatic Agents / adverse effects Arthritis, Rheumatoid / drug therapy, pathology*, radiography Cyclooxygenase Inhibitors / adverse effects Humans Male Pulmonary Fibrosis / pathology Pyrazoles Sulfasalazine / adverse effects Sulfonamides / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 0/Cyclooxygenase Inhibitors; 0/Pyrazoles; 0/Sulfonamides; 169590-42-5/celecoxib; 599-79-1/Sulfasalazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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