Document Detail

Migratory pulmonary infiltrates in a patient with rheumatoid arthritis.
MedLine Citation:
PMID:  11978928     Owner:  NLM     Status:  MEDLINE    
The case history is described of an elderly man with rheumatoid arthritis receiving treatment with sulfasalazine and the cyclooxygenase-2 inhibitor celecoxib who presented with severe shortness of breath, cough, and decreased exercise tolerance. The chest radiograph showed unilateral alveolo-interstitial infiltrates and a biopsy specimen of the lung parenchyma showed changes consistent with acute eosinophilic pneumonia. Antibiotic treatment was unsuccessful, but treatment with steroids and discontinuation of sulfasalazine and celecoxib resulted in a marked clinical improvement confirmed by arterial blood gas analysis. The condition may have developed as an adverse reaction either to sulfasalazine or to celecoxib, although hypersensitivity to the latter has not previously been reported.
S Mehandru; R L Smith; G S Sidhu; N Cassai; C P Aranda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Thorax     Volume:  57     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-29     Completed Date:  2002-06-13     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  465-7     Citation Subset:  IM    
Departments of Medicine and Pathology, School of Medicine, New York University, New York, USA.
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MeSH Terms
Airway Obstruction / chemically induced,  pathology*,  radiography
Antirheumatic Agents / adverse effects
Arthritis, Rheumatoid / drug therapy,  pathology*,  radiography
Cyclooxygenase Inhibitors / adverse effects
Pulmonary Fibrosis / pathology
Sulfasalazine / adverse effects
Sulfonamides / adverse effects
Reg. No./Substance:
0/Antirheumatic Agents; 0/Cyclooxygenase Inhibitors; 0/Pyrazoles; 0/Sulfonamides; 169590-42-5/celecoxib; 599-79-1/Sulfasalazine

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