| Migration resistant, blood-compatible plasticized polyvinyl chloride for medical and related applications. | |
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MedLine Citation:
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PMID: 9527283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasticized polyvinyl chloride (PVC), although not a blood-compatible polymer, is the material of choice for the manufacture of blood bags and hemodialysis tubing throughout the world. PVC is usually plasticized with di-(2-ethylhexyl phthalate) (DEHP) to impart flexibility and low temperature properties to the final product. DEHP belongs to a class of agents called hypolipidemic hepatocarcinogens, and it migrates in small quantities into the storage medium such as blood, plasma, or serum, resulting in a number of toxic effects. It has been shown that the migration resistance and blood compatibility of flexible PVC could be significantly improved by grafting polyethylene glycol (PEG), the most blood-compatible polymer known today, onto the surface of flexible PVC by the classical Williamson ether synthesis reaction. The technique is simple and versatile enough to produce blood-compatible, migration resistant PVC surfaces for many medical applications. The method may also find use for preventing plasticizer migration from PVC cling films and polyvinylidene chloride films used extensively in food packaging. |
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Authors:
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S Lakshmi; A Jayakrishnan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Artificial organs Volume: 22 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-05-20 Completed Date: 1998-05-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 222-9 Citation Subset: IM |
Affiliation:
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Polymer Chemistry Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticoagulants / chemistry* Biocompatible Materials* Blood Platelets / drug effects, ultrastructure Carcinogens / chemistry, metabolism Diethylhexyl Phthalate / chemistry, metabolism Microscopy, Electron, Scanning Plasticizers / chemistry, metabolism Platelet Adhesiveness / drug effects Polyethylene Glycols / chemistry*, pharmacology Polyvinyl Chloride / chemistry*, metabolism Rabbits Thrombosis / prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Biocompatible Materials; 0/Carcinogens; 0/Plasticizers; 0/Polyethylene Glycols; 117-81-7/Diethylhexyl Phthalate; 9002-86-2/Polyvinyl Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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