Document Detail


Migration of microchimeric fetal cells into maternal circulation before placenta formation.
MedLine Citation:
PMID:  21327051     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fetal cell microchimerism is defined as the persistence of pluripotent fetal cells in the maternal body long after delivery. The exact process by which fetal cells cross the placental barrier and enter maternal circulation is still being investigated. We reported that fetal cells persist only in the maternal bone marrow and may give rise to subpopulations with the ability to differentiate into the tissue-specific mature cells within injured maternal organs. Moreover, most of the fetal cells enter the maternal circulation during the early stages of pregnancy. These results indicate that the fetal cells with a multilineage potential, which were detected in a variety of maternal organs during pregnancy did not pass through the placental barrier; rather, they were derived from the fetal cells that entered maternal circulation early after implantation, and sustained their population long after delivery.
Authors:
Rei Sunami; Mayuko Komuro; Hikaru Tagaya; Shuji Hirata
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Chimerism (Print)     Volume:  1     ISSN:  1938-1964     ISO Abbreviation:  -     Publication Date:  2010 10 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101540510     Medline TA:  Chimerism     Country:  -    
Other Details:
Languages:  ENG     Pagination:  66-68     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology; University of Yamanashi; Chuo, Yamanashi Japan.
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