| Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro. | |
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MedLine Citation:
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PMID: 7553628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The invasion and migration occurring in primary neoplastic tissue explants were studied by using a three-dimensional collagen matrix model, subsequent time-lapse videomicroscopy, and computer-assisted cell tracking. We show that not only single cells but groups of clustered cells comprising 5 to more than 100 cells detach from the primary tumor lesion and migrate within the adjacent extracellular matrix. These clusters were highly polarized, resulting in a high directional persistence of migration. Locomoting cell clusters were observed in primary cultures from invasive oral squamous cell carcinomas (6 of 9), ductal breast carcinomas (2 of 3), and rhabdomyosarcoma (1 of 1), whereas normal oral mucosa (0 of 4) was cell cluster negative. Thus, locomoting cell clusters could be a novel and potentially important mechanism of cancer cell invasion and metastasis. |
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Authors:
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P Friedl; P B Noble; P A Walton; D W Laird; P J Chauvin; R J Tabah; M Black; K S Zänker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer research Volume: 55 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-11-08 Completed Date: 1995-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4557-60 Citation Subset: IM |
Affiliation:
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Institute of Immunology, University of Witten/Herdecke, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Ductal, Breast
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pathology Carcinoma, Squamous Cell / pathology Cell Movement* Collagen Epithelial Cells Extracellular Matrix Humans Mesoderm / cytology Rhabdomyosarcoma / pathology Tumor Cells, Cultured / cytology* Video Recording |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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