Document Detail


Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro.
MedLine Citation:
PMID:  7553628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The invasion and migration occurring in primary neoplastic tissue explants were studied by using a three-dimensional collagen matrix model, subsequent time-lapse videomicroscopy, and computer-assisted cell tracking. We show that not only single cells but groups of clustered cells comprising 5 to more than 100 cells detach from the primary tumor lesion and migrate within the adjacent extracellular matrix. These clusters were highly polarized, resulting in a high directional persistence of migration. Locomoting cell clusters were observed in primary cultures from invasive oral squamous cell carcinomas (6 of 9), ductal breast carcinomas (2 of 3), and rhabdomyosarcoma (1 of 1), whereas normal oral mucosa (0 of 4) was cell cluster negative. Thus, locomoting cell clusters could be a novel and potentially important mechanism of cancer cell invasion and metastasis.
Authors:
P Friedl; P B Noble; P A Walton; D W Laird; P J Chauvin; R J Tabah; M Black; K S Zänker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  55     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-08     Completed Date:  1995-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4557-60     Citation Subset:  IM    
Affiliation:
Institute of Immunology, University of Witten/Herdecke, Germany.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Ductal, Breast / pathology
Carcinoma, Squamous Cell / pathology
Cell Movement*
Collagen
Epithelial Cells
Extracellular Matrix
Humans
Mesoderm / cytology
Rhabdomyosarcoma / pathology
Tumor Cells, Cultured / cytology*
Video Recording
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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