Document Detail

Migration of 15 micron microspheres from infarcted myocardium.
MedLine Citation:
PMID:  7388859     Owner:  NLM     Status:  MEDLINE    
The fate of 15 micrometers microspheres in ischaemic myocardial tissue was investigated. The spheres were delivered to the left atrium before acute coronary artery ligation. 10 h later the myocardium was examined for its contents of preocclusion spheres, as well as spheres delivered immediately before sacrifice. The ischaemic tissue contained 11 to 60% less preocclusion spheres, compared with nonischaemic tissue in the same hearts. On average, 26% of preocclusion spheres were lost during the 10 h period. Negligible amounts of the lost spheres could be retrieved from cardiac lymph nodes in the mediastinum. Most likely, the spheres migrated through venous pathways; a substantial number of preocclusion spheres were present in the lungs after 10 h, the bulk of which had originated from other organs than the infarct. These results quantify an important limitation to the use of microsphere distribution as a method for tissue blood flow measurements in infarcted myocardium when the period of coronary artery occlusion exceeds a few hours.
J Lekven; K S Andersen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  14     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-09-26     Completed Date:  1980-09-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  280-7     Citation Subset:  IM    
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MeSH Terms
Coronary Circulation*
Coronary Vessels / radionuclide imaging
Lung / blood supply
Lymph Nodes / blood supply
Myocardial Infarction / physiopathology*
Time Factors

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