| Migrating focal seizures in infancy: analysis of the electroclinical patterns in 17 patients. | |
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MedLine Citation:
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PMID: 18230844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe the electroclinical features, therapy, and long-term evolution of 17 patients with migrating focal seizures in infancy, and analyzed the charts of these patients seen between February 1985 and July 2005. Three different electroclinical patterns were recognized: (1) 8 cases with alternating simple focal motor seizures at onset. The ictal electroencephalography (EEG) pattern was characterized by recurrence of rhythmic focal spikes or rhythmic sharp activity in the Rolandic region; (2) 5 cases with complex focal seizures and progressive appearance of polymorphic delta- activity in 1 temporo-occipital region recurring independently; (3) 4 cases with focal complex seizures with motor manifestations. Ictal EEG showed flattening or fast activity in 1 frontotemporal region followed by unilateral fast poly-spikes in alternating clusters in both hemispheres. The focal seizures were refractory to antiepileptic drugs, and all patients except 3 had severe developmental delay. Migrating focal seizures in infancy is a newly defined and rare, but underrecognized, epileptic encephalopathy. |
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Authors:
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Roberto Horacio Caraballo; Elena Fontana; Francesca Darra; Laura Cassar; Francesca Negrini; Elena Fiorini; Hugo Arroyo; Stella Ferraro; Natalio Fejerman; Bernardo Dalla Bernardina |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2008-01-29 |
Journal Detail:
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Title: Journal of child neurology Volume: 23 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-01 Completed Date: 2008-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: Canada |
Other Details:
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Languages: eng Pagination: 497-506 Citation Subset: IM |
Affiliation:
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Neurology Department, Hospital de Pediatría Prof Dr Juan P. Garrahan, Combate de los Pozos 1881, CP 1245, Buenos Aires, Argentina. rhcaraballo@arnet.com.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Electroencephalography* Female Follow-Up Studies Humans Infant Infant, Newborn Male Retrospective Studies Seizures / classification*, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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